Compile Data Set for Download or QSAR
maximum 50k data
Found 49 Enz. Inhib. hit(s) with all data for entry = 50008478
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519643(CHEMBL4455611)
Affinity DataKi:  21nMAssay Description:Inhibition of human RIPK1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519643(CHEMBL4455611)
Affinity DataKi:  189nMAssay Description:Inhibition of mouse RIPK1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine kinase 1(Rattus norvegicus)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519643(CHEMBL4455611)
Affinity DataKi:  691nMAssay Description:Inhibition of rat RIPK1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human RIPK1 by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of GSK657 binding to human RIPK1 (1 to 328) by fluorescence Polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human His-tagged RIPK2 (8 to 317 residues) incubated for 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519642(CHEMBL4469781)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human RIPK1 by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of Abl (unknown origin) incubated for 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant GST-tagged RIPK3 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519642(CHEMBL4469781)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of GSK657 binding to human RIPK1 (1 to 328) by fluorescence Polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  2nMAssay Description:Inhibition of human RIPK3 using MBP as substrate by [gamma33-ATP] based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519648(CHEMBL4441118)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of human RIPK1 by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519648(CHEMBL4441118)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of GSK657 binding to human RIPK1 (1 to 328) by fluorescence Polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant GST-tagged RIPK1 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human GST-tagged RIPK1 (1 to 479 residues) incubated for 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519650(CHEMBL4474235)
Affinity DataIC50:  21nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442162(CHEMBL2441342)
Affinity DataIC50:  69nMAssay Description:Inhibition of recombinant human GST-tagged RIPK1 (1 to 479 residues) incubated for 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM25193(4-methyl-3-{[7-(pyridin-2-yl)quinolin-4-yl]amino}p...)
Affinity DataIC50:  74nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  77nMAssay Description:Inhibition of human RIPK2 using MBP as substrate by [gamma33-ATP] based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519646(CHEMBL4464634)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant GST-tagged RIPK1 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519645(CHEMBL4464023)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant RIPK1 (unknown origin) using MBP as substrate preincubated for 15 mins followed by addition of MBP and measured after 120 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM36371(5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidaz...)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human IDO using L-Trp as substrate incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
Fudan University

Curated by ChEMBL
LigandPNGBDBM423400(US10501473, Example 39)
Affinity DataIC50:  110nMAssay Description:Inhibition of RIPK1 in mouse RGC-5 cells incubated for 30 mins in presence of [gamma32-ATP] by SDS-PAGE based radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519639(CHEMBL366011)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human IDO using L-Trp as substrate incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519644(CHEMBL4453780)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant RIPK1 (unknown origin) using MBP as substrate preincubated for 15 mins followed by addition of MBP and measured after 120 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519640(CHEMBL4569395)
Affinity DataIC50:  200nMAssay Description:Inhibition of RIPK3 in human HT-29 cells assessed as reduction in TSZ-induced necroptosis by Cell Titer Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  250nMAssay Description:Inhibition of human full length N-terminal GST-tagged RIPK3 expressed in baculovirus infected sf9 insect cells assessed as reduction in MBP phosphory...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50263057(CHEMBL381230)
Affinity DataIC50:  320nMAssay Description:Inhibition of RIPK1 (1 to 312 residues) (unknown origin) preincubated for 15 mins followed by addition of [gamma32P] ATP and measured after 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM26474(5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  873nMAssay Description:Inhibition of RIPK1 in human HT-29 cells assessed as reduction in TNFalpha-induced necroptosis incubated for 14 to 24 hrs in presence of Smac mimetic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519646(CHEMBL4464634)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Abl (unknown origin) incubated for 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519644(CHEMBL4453780)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant RIPK3 (unknown origin) using MBP as substrate preincubated for 15 mins followed by addition of MBP and measured after 120 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519645(CHEMBL4464023)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant RIPK3 (unknown origin) using MBP as substrate preincubated for 15 mins followed by addition of MBP and measured after 120 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519646(CHEMBL4464634)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant GST-tagged RIPK3 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519641(CHEMBL4439426)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of human full length GST-tagged RIPK1 expressed in baculovirus in Sf9 insect cells incubated for 10 mins in presence of [gamma32-ATP] by S...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519646(CHEMBL4464634)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of recombinant human His-tagged RIPK2 (8 to 317 residues) incubated for 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  1.45E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged RIPK3 expressed in baculovirus infected sf9 insect cells assessed as reduction in MBP phosphory...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual serine/threonine and tyrosine protein kinase(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  2.94E+4nMAssay Description:Inhibition of human RIPK5 using MBP as substrate by [gamma33-ATP] based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  5.32E+4nMAssay Description:Inhibition of human RIPK1 using MBP as substrate by [gamma33-ATP] based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM36371(5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidaz...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of IDO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to human RIPK1 by kinome scan based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519651(CHEMBL4534082)
Affinity DataKd:  130nMAssay Description:Binding affinity to human RIPK1 by kinome scan based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMixed lineage kinase domain-like protein(Homo sapiens)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519647(CHEMBL4440337)
Affinity DataKd:  230nMAssay Description:Binding affinity to human MLKL by kinome scan based methodMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519641(CHEMBL4439426)
Affinity DataKd:  218nMAssay Description:Binding affinity to human RIPK1 by kinome scan based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  6.70E+3nMAssay Description:Binding affinity to human RIPK3 by kinome scan based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMixed lineage kinase domain-like protein(Homo sapiens)
Fudan University

Curated by ChEMBL
LigandPNGBDBM5832(3-{4-[methyl({2-[(3-sulfamoylphenyl)amino]pyrimidi...)
Affinity DataKd:  9.30E+3nMAssay Description:Binding affinity to MLKL (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519647(CHEMBL4440337)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to human RIPK3 by kinome scan based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519647(CHEMBL4440337)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to human RIPK1 by kinome scan based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMixed lineage kinase domain-like protein(Homo sapiens)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  217nMAssay Description:Binding affinity to human MLKL by kinome scan based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed