Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50007077
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506051(CHEMBL4587988)
Affinity DataIC50: 2nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506050(CHEMBL4580481)
Affinity DataIC50: 4nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506053(CHEMBL4562740)
Affinity DataIC50: 4nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506052(CHEMBL4446191)
Affinity DataIC50: 4nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506049(CHEMBL4466072)
Affinity DataIC50: 5nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506056(CHEMBL4554462)
Affinity DataIC50: 5nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 5nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506057(CHEMBL4444848)
Affinity DataIC50: 7nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506050(CHEMBL4580481)
Affinity DataIC50: 15nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506047(CHEMBL4551475)
Affinity DataIC50: 21nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506049(CHEMBL4466072)
Affinity DataIC50: 21nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506046(CHEMBL4549748)
Affinity DataIC50: 21nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506051(CHEMBL4587988)
Affinity DataIC50: 23nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506054(CHEMBL4440185)
Affinity DataIC50: 29nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506052(CHEMBL4446191)
Affinity DataIC50: 32nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 70nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506056(CHEMBL4554462)
Affinity DataIC50: 84nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506055(CHEMBL4582076)
Affinity DataIC50: 105nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506057(CHEMBL4444848)
Affinity DataIC50: 111nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506049(CHEMBL4466072)
Affinity DataIC50: 120nMAssay Description:Inhibition of human GAL4-DBD fused RORgammat LBD expressed in human Jurkat cells assessed as inhibition of receptor transactivation after 24 hrs by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506057(CHEMBL4444848)
Affinity DataIC50: 120nMAssay Description:Inhibition of human GAL4-DBD fused RORgammat LBD expressed in human Jurkat cells assessed as inhibition of receptor transactivation after 24 hrs by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506058(CHEMBL4435228)
Affinity DataIC50: 128nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 151nMAssay Description:Inhibition of human GAL4-DBD fused RORgammat LBD expressed in human Jurkat cells assessed as inhibition of receptor transactivation after 24 hrs by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 151nMAssay Description:Inhibition of Gal4-tagged RORgammat LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506056(CHEMBL4554462)
Affinity DataIC50: 160nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506053(CHEMBL4562740)
Affinity DataIC50: 189nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506049(CHEMBL4466072)
Affinity DataIC50: 331nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506046(CHEMBL4549748)
Affinity DataIC50: 393nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506050(CHEMBL4580481)
Affinity DataIC50: 425nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506054(CHEMBL4440185)
Affinity DataIC50: 452nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 1.34E+3nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506057(CHEMBL4444848)
Affinity DataIC50: 1.67E+3nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506059(CHEMBL4470986)
Affinity DataIC50: 1.90E+3nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Gal4-tagged PPARgamma LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Gal4-tagged VDR LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Gal4-tagged FXR LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Gal4-tagged PR LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Gal4-tagged ERalpha LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Gal4-tagged RORbeta LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Gal4-tagged RXRalpha LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Gal4-tagged GR LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Gal4-tagged PXR LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506048(CHEMBL4513808)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Gal4-tagged RORalpha LBD (unknown origin) by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed