Compile Data Set for Download or QSAR
Report error Found 68 Enz. Inhib. hit(s) with all data for entry = 50009508
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataIC50: 1nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529395(CHEMBL4529672 | US11731973, Example 21)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529395(CHEMBL4529672 | US11731973, Example 21)
Affinity DataIC50: 4nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataIC50: 5nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529393(CHEMBL4564479 | US11731973, Example 24)
Affinity DataIC50: 5nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529393(CHEMBL4564479 | US11731973, Example 24)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529393(CHEMBL4564479 | US11731973, Example 24)
Affinity DataIC50: 7nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529407(CHEMBL4572049)
Affinity DataIC50: 7nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529398(CHEMBL4549761 | US11731973, Example 31)
Affinity DataIC50: 8nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529398(CHEMBL4549761 | US11731973, Example 31)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529407(CHEMBL4572049)
Affinity DataKi:  11nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529395(CHEMBL4529672 | US11731973, Example 21)
Affinity DataIC50: 11nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529399(CHEMBL4538004)
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529404(CHEMBL4441763)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529407(CHEMBL4572049)
Affinity DataIC50: 20nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529398(CHEMBL4549761 | US11731973, Example 31)
Affinity DataIC50: 20nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529405(CHEMBL4588610)
Affinity DataKi:  21nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529401(CHEMBL4585005)
Affinity DataKi:  28nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataKi:  28nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529401(CHEMBL4585005)
Affinity DataIC50: 30nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529396(CHEMBL4538629)
Affinity DataIC50: 30nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529396(CHEMBL4538629)
Affinity DataKi:  33nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529405(CHEMBL4588610)
Affinity DataIC50: 35nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529402(CHEMBL4517253)
Affinity DataKi:  40nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529394(CHEMBL4475845)
Affinity DataIC50: 40nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529399(CHEMBL4538004)
Affinity DataIC50: 40nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529404(CHEMBL4441763)
Affinity DataIC50: 40nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529402(CHEMBL4517253)
Affinity DataIC50: 45nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529392(CHEMBL4461815)
Affinity DataKi:  50nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529405(CHEMBL4588610)
Affinity DataIC50: 60nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529392(CHEMBL4461815)
Affinity DataIC50: 60nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529394(CHEMBL4475845)
Affinity DataKi:  62nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529399(CHEMBL4538004)
Affinity DataIC50: 80nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529392(CHEMBL4461815)
Affinity DataKi:  85nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529402(CHEMBL4517253)
Affinity DataIC50: 90nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529396(CHEMBL4538629)
Affinity DataIC50: 90nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529401(CHEMBL4585005)
Affinity DataIC50: 130nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529392(CHEMBL4461815)
Affinity DataIC50: 140nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529395(CHEMBL4529672 | US11731973, Example 21)
Affinity DataKi:  150nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529403(CHEMBL4456417)
Affinity DataKi:  190nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529404(CHEMBL4441763)
Affinity DataIC50: 200nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529394(CHEMBL4475845)
Affinity DataIC50: 200nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529403(CHEMBL4456417)
Affinity DataIC50: 240nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529406(CHEMBL4525459)
Affinity DataKi:  250nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529403(CHEMBL4456417)
Affinity DataIC50: 360nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529406(CHEMBL4525459)
Affinity DataKi:  370nMAssay Description:Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50529406(CHEMBL4525459)
Affinity DataIC50: 420nMAssay Description:Inhibition of mTORC1 in human A431 cells assessed as S6RP phosphorylation incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529406(CHEMBL4525459)
Affinity DataIC50: 680nMAssay Description:Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529393(CHEMBL4564479 | US11731973, Example 24)
Affinity DataKi:  780nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
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