Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50007102
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8146(N-(3,5-dimethylphenyl)-4-{pyrazolo[1,5-a]pyridazin...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8136(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{pyrazolo[1...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8137(N-(3,4-difluorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8128(N-(3-methoxyphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8146(N-(3,5-dimethylphenyl)-4-{pyrazolo[1,5-a]pyridazin...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8126(N-phenyl-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidi...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8136(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{pyrazolo[1...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8128(N-(3-methoxyphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8137(N-(3,4-difluorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50506295(GW801372X)
Affinity DataIC50: 13nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50506295(GW801372X)
Affinity DataIC50: 16nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50506295(GW801372X)
Affinity DataIC50: 20nMAssay Description:Inhibition of human CDK4 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8126(N-phenyl-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidi...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8197(4-{6-methyl-2-phenylpyrazolo[1,5-a]pyridazin-3-yl}...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8152(4-{6-methoxypyrazolo[1,5-a]pyridazin-3-yl}-N-[3-(t...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8189(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{2-[3-(trif...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8133(N-(4-tert-butylphenyl)-4-{pyrazolo[1,5-a]pyridazin...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8128(N-(3-methoxyphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human CDK4 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8126(N-phenyl-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidi...)
Affinity DataIC50: 158nMAssay Description:Inhibition of human CDK4 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8133(N-(4-tert-butylphenyl)-4-{pyrazolo[1,5-a]pyridazin...)
Affinity DataIC50: 158nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8152(4-{6-methoxypyrazolo[1,5-a]pyridazin-3-yl}-N-[3-(t...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8136(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{pyrazolo[1...)
Affinity DataIC50: 316nMAssay Description:Inhibition of human CDK4 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8146(N-(3,5-dimethylphenyl)-4-{pyrazolo[1,5-a]pyridazin...)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of human CDK4 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8133(N-(4-tert-butylphenyl)-4-{pyrazolo[1,5-a]pyridazin...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human CDK4 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8181(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-[2-(4-metho...)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8217(N-(2-methylphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-y...)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8197(4-{6-methyl-2-phenylpyrazolo[1,5-a]pyridazin-3-yl}...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8181(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-[2-(4-metho...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8152(4-{6-methoxypyrazolo[1,5-a]pyridazin-3-yl}-N-[3-(t...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CDK4 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8182(N-phenyl-4-{2-[4-(trifluoromethyl)phenyl]pyrazolo[...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8213(4-{2-cyclopropylpyrazolo[1,5-a]pyridazin-3-yl}-N-(...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8189(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{2-[3-(trif...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CDK2 using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8213(4-{2-cyclopropylpyrazolo[1,5-a]pyridazin-3-yl}-N-(...)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM8182(N-phenyl-4-{2-[4-(trifluoromethyl)phenyl]pyrazolo[...)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed