Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50010943
TargetSerine/threonine-protein kinase mTOR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 36609BDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTOR in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20800BDBM20800(CHEMBL467399 | 6-chloro-9-[(4-methoxy-3,5-dimethyl...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of recombinant His-tagged full length human HSP90 (9 to 236 residues) expressed in Escherichia coli BL21(DE3) cells after 18 hrs by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50088378BDBM50088378(CHEBI:68478 | Afinitor | Afinitor Disperz | Everol...)
Affinity DataIC50: 5nMAssay Description:Inhibition of mTOR in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 66431BDBM66431(2-(3-chloro-N-(2-chloroacetyl)-4-methoxyanilino)-N...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Vps34 (unknown origin) interaction with PIK3 assessed as reduction in autophagy by increasing LC3 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50087135BDBM50087135(CHEMBL3426621)
Affinity DataIC50: 19nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50543600BDBM50543600(CHEMBL4639853)
Affinity DataIC50: 19nMAssay Description:Inhibition of Vps34 in human MCF7-LC3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50543601BDBM50543601(CHEMBL2134202)
Affinity DataKi:  20nMAssay Description:Inhibition of S6K1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 92862BDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 21nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 66431BDBM66431(2-(3-chloro-N-(2-chloroacetyl)-4-methoxyanilino)-N...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Vps34 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50543600BDBM50543600(CHEMBL4639853)
Affinity DataIC50: 40nMAssay Description:Inhibition of Vps34 in human MCF7-LC3 cells assessed as rapamycin-induced autophagyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50087135BDBM50087135(CHEMBL3426621)
Affinity DataIC50: 51nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50543600BDBM50543600(CHEMBL4639853)
Affinity DataIC50: 90nMAssay Description:Inhibition of Vps34 in human MCF7-LC3 cells assessed as starvation-induced autophagyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50543601BDBM50543601(CHEMBL2134202)
Affinity DataIC50: 160nMAssay Description:Inhibition of S6K1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUDP-glucuronosyltransferase 1A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068270BDBM50068270(3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)ph...)
Affinity DataIC50: 970nMAssay Description:Induction of UGT1A1 (unknown origin) assessed as increase in intracellular acidic autophagy vesicles formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205338BDBM50205338(CHEMBL3948237)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of GST/His-tagged human KEAP1 (321 to 609 residues) interaction with phosphorylated p62 expressed in Escherichia coli cells by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA polymerase alpha catalytic subunit(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23926BDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human DNA polymerase-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017716BDBM50017716(CHEMBL282567 | 2-Benzhydryl-pentanoic acid 2-dieth...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed