Found 23 Enz. Inhib. hit(s) with all data for entry = 50011299 TargetRho-associated protein kinase 1(Homo sapiens (Human))
Taipei Medical University
Curated by ChEMBL
Taipei Medical University
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Inhibition of human ROCK1 expressed in baculovirus expression system by Kinase-Glo luminescent AssayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Taipei Medical University
Curated by ChEMBL
Taipei Medical University
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Inhibition of human ROCK2 expressed in baculovirus expression system by Kinase-Glo luminescent AssayMore data for this Ligand-Target Pair
Affinity DataKi: 0.970nMAssay Description:Binding affinity to A1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to A3 receptor (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Taipei Medical University
Curated by ChEMBL
Taipei Medical University
Curated by ChEMBL
Affinity DataKi: 4.20nMAssay Description:Inhibition of human ROCK2 by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Taipei Medical University
Curated by ChEMBL
Taipei Medical University
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of ROCK2 (unknown origin) using histone as substrate incubated for 20 mins in presence of [gamma32P]-ATP by liquid scintillation counter m...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of CFD in 10% human serum assessed as reduction in alternate complement pathway-mediated hemolysis incubated for 1 hrMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Taipei Medical University
Curated by ChEMBL
Taipei Medical University
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal GST-fused human ROCK2 catalytic domain ( 1 to 553 residues) expressed in baculovirus expression system using Long S6 Kinase ...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of CFD in 50% human whole blood assessed as reduction in alternate complement pathway-mediated MAC formation pre-incubated for 15 mins fol...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Taipei Medical University
Curated by ChEMBL
Taipei Medical University
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of N-terminal GST-fused human ROCK1 catalytic domain ( 1 to 477 residues) expressed in baculovirus expression system using Long S6 Kinase ...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of CFD in human RBC model of anti-CD55/anti-CD59-induced paroxysmal nocturnal hemoglobinuria assessed as reduction in complement fragment ...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of CFD in 50% human whole blood assessed as reduction in alternate complement pathway-mediated MAC formation pre-incubated for 15 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of C5 complement protein in 2% human serum incubated for 15 minsMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Taipei Medical University
Curated by ChEMBL
Taipei Medical University
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)TargetRho-associated protein kinase 2(Homo sapiens (Human))
Taipei Medical University
Curated by ChEMBL
Taipei Medical University
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of C5 complement protein in 2% human serum incubated for 15 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 620nMAssay Description:Inhibition of C5 complement protein in 2% human serum incubated for 15 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of recombinant human CFD catalytic domain (G24 to A253 residues) expressed in Escherichia coli (Rosetta) using Z-Lys-thiobenzyl and 2,4-di...More data for this Ligand-Target Pair
Affinity DataIC50: >1.40E+4nMAssay Description:Inhibition of recombinant human CFD catalytic domain (G24 to A253 residues) expressed in Escherichia coli (Rosetta) using Z-Lys-thiobenzyl and 2,4-di...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human CFD catalytic domain (G24 to A253 residues) expressed in Escherichia coli (Rosetta) using Z-Lys-thiobenzyl and 2,4-di...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Taipei Medical University
Curated by ChEMBL
Taipei Medical University
Curated by ChEMBL
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of LPS/IFN-gamma induced NO-dependent iNOS activity in mouse RAW 264.7 cells incubated for 16 hrs by Griess reagent based assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.60E+6nMAssay Description:Binding affinity to 15N-labeled human CFD by 1H-15N-HSQC NMR analysisMore data for this Ligand-Target Pair
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to human CFD at 100 uM by WaterLOGSY NMR analysisMore data for this Ligand-Target Pair
