Compile Data Set for Download or QSAR
maximum 50k data
Found 38 Enz. Inhib. hit(s) with all data for entry = 50010546
LigandPNGBDBM50540028(CHEMBL4635769)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540030(CHEMBL4633392)
Affinity DataIC50:  2nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540025(CHEMBL4639517)
Affinity DataIC50:  2nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540029(CHEMBL4648587)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540026(CHEMBL4645846)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  7nMAssay Description:Inhibition of autotaxin in mouse plasma assessed as reduction in LPA (18:2) production incubated for 2 hrs LC-MS-/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM370043((R)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-4-oxo-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  14nMAssay Description:Inhibition of autotaxin in human plasma assessed as reduction in LPA (18:2) production incubated for 2 hrs LC-MS-/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM370050((R)-4-(8-(2-(2-Fluoro-5-(trifluoromethyl)benzamido...)
Affinity DataIC50:  31nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369944((R)—N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  34nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM370016((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-2,4-dioxo-1-p...)
Affinity DataIC50:  38nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM370019((R)—N-(1-(1-(3-Chlorophenyl)-3-methyl-2,4-dio...)
Affinity DataIC50:  46nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  55nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540028(CHEMBL4635769)
Affinity DataIC50:  56nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540025(CHEMBL4639517)
Affinity DataIC50:  86nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369934((R)-2-Fluoro-N-(3-methyl-1-(3-methyl-2,4-dioxo-1-p...)
Affinity DataIC50:  100nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369946(US10233182, Example 59)
Affinity DataIC50:  340nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540027(CHEMBL4638762)
Affinity DataIC50:  350nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369899((R)-3-Methyl-N-(2-(3-methyl-4-oxo-1-phenyl-1,3,8-t...)
Affinity DataIC50:  623nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369876((R)-2-Fluoro-3-methyl-N-(3-methyl-1-(3-methyl-2,4-...)
Affinity DataIC50:  683nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540031(CHEMBL4646195)
Affinity DataIC50:  819nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540032(CHEMBL4636626)
Affinity DataIC50:  905nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369827((R)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369824((R)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ENPP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LPAR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 3(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LPAR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369852((S)-3-Methyl-N-(2-(3-methyl-4-oxo-1-phenyl-1,3,8-t...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369828((S)—N-(1-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LPAR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369829(N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-dioxo-1,3,8...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human ERG by GLP based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human ERG by manual patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed