BindingDB PrimarySearch

Found 32 Enz. Inhib. hit(s) with all data for entry = 50010550

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540037(CHEMBL4639341)

IC50: 0.900nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540040(CHEMBL4640793)

IC50: 1.5nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540042(CHEMBL4647278)

IC50: 2.60nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: 2.90nMAssay Description:Inhibition of PDE1B (146 to 506 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: 2.90nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540035(CHEMBL4649493)

IC50: 4.70nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540039(CHEMBL4639286)

IC50: 20nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540035(CHEMBL4649493)

IC50: 23nMAssay Description:Inhibition of PDE1B (146 to 506 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540046(CHEMBL4638381)

IC50: 27nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540038(CHEMBL4642557)

IC50: 57nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540047(CHEMBL4644938)

IC50: 58nMAssay Description:Inhibition of PDE9A (181 to 506 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540045(CHEMBL4634240)

IC50: 65nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540047(CHEMBL4644938)

IC50: 80nMAssay Description:Inhibition of PDE1B (146 to 506 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540041(CHEMBL4632429)

IC50: 157nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540043(CHEMBL4636141)

IC50: 245nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540036(CHEMBL4632723)

IC50: 258nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: 370nMAssay Description:Inhibition of PDE5A1 (535 to 860 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: 699nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) using [3H]-cAMP substrate incubated for 15 mins by liquid scintillation counting method re...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: 1.77E+3nMAssay Description:Inhibition of PDE10A (449 to 770 residues) (unknown origin) using [3H]-cAMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: 2.02E+3nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) using [3H]-cAMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Cytochrome P450 2C9(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: 6.60E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE2A (580 to 919 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting method re...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE7A1 (130 to 482 residues) (unknown origin) using [3H]-cAMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE9A2 (181 to 506 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540035(CHEMBL4649493)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE9A (181 to 506 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE3A (679 to 1087 residues) (unknown origin) using [3H]-cAMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE6C (1 to 858 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting method rela...More data for this Ligand-Target Pair

UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: 1.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Cytochrome P450 3A4(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: >2.50E+4nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Cytochrome P450 3A4(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: >2.50E+4nMAssay Description:Inhibition of human CYP3A4 using testosterone as substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Cytochrome P450 2D6(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: >2.50E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

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Cytochrome P450 1A2(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50540044(CHEMBL4644729)

IC50: >2.50E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Filter my 32 hits

Targets 16▿
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 12
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 3
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 3
- Cytochrome P450 3A4 2
- cGMP-specific 3',5'-cyclic phosphodiesterase 1
- Cytochrome P450 1A2 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 1
- Cytochrome P450 2C9 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase 1
- Cytochrome P450 2D6 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1
- Potassium voltage-gated channel subfamily H member 2 1
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 1
Publications 1▿
- J Med Chem 63: 7867-7879 (2020) 32
Institutions 1▿
- Sun Yat-Sen University 32
Affinity: 0.90 to 2.5E+4 nM▿
- IC50 32
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0