Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50015710
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL63064 | N-(2,5-Dimethoxy-benzyl)-N-(5-fluoro...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of TSPO receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50421116(CHEMBL2088374)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to TSPO (unknown origin) relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM22041(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to TSPO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588817(CHEMBL5193551)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-flunitrazepam from TSPO receptor in Wistar rat brain without cerebellum incubated for 90 mins by liquid scintillation counter an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50185957(N-(4-chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl...)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of TSPO receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-flunitrazepam from TSPO receptor in Wistar rat brain without cerebellum incubated for 90 mins by liquid scintillation counter an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588815(CHEMBL5208364)
Affinity DataKi:  4.90nMAssay Description:Binding affinity to TSPO in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588814(CHEMBL5181329)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]-PK11195 from TSPO receptor in Sprague-Dawley rat brain incubated for 30 mins by auto-gamma scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588812(CHEMBL5179737)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of TSPO receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50243007(N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-di...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-PK11195 from TSPO receptor in Wistar rat Kidney assessed as inhibition constant incubated for 90 mins by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM22041(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]-flunitrazepam from TSPO receptor in Wistar rat brain without cerebellum incubated for 90 mins by liquid scintillation counter an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50229594(N-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)aceta...)
Affinity DataIC50: 8.10nMAssay Description:Displacement of [3H]-PK11195 from TSPO receptor in human Leucocyte incubated for 30 mins by beta-counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588813(CHEMBL5199978)
Affinity DataIC50: 8.30nMAssay Description:Displacement of [3H]-PK11195 from TSPO receptor in human Leucocyte incubated for 30 mins by beta-counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588820(CHEMBL5181262)
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]-Ro54864 from TSPO receptor in rat heart microsomes incubated for 45 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588823(CHEMBL5183217)
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]-PK11195 from TSPO receptor in rat heart microsomes incubated for 15 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588823(CHEMBL5183217)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]-Ro54864 from TSPO receptor in rat heart microsomes incubated for 45 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50579426(CHEMBL330116 | CGS-13767)
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]-Ro54864 from TSPO receptor in rat heart microsomes incubated for 45 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588816(CHEMBL5191240)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]-flunitrazepam from TSPO receptor in Wistar rat brain without cerebellum incubated for 90 mins by liquid scintillation counter an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588820(CHEMBL5181262)
Affinity DataIC50: 29nMAssay Description:Displacement of [3H]-PK11195 from TSPO receptor in rat heart microsomes incubated for 15 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588821(CHEMBL5200308)
Affinity DataIC50: 80nMAssay Description:Displacement of [3H]-Ro54864 from TSPO receptor in rat heart microsomes incubated for 45 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588822(CHEMBL5202023)
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]-PK11195 from TSPO receptor in rat heart microsomes incubated for 15 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50060095(2-[6,8-Dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]...)
Affinity DataEC50:  337nMAssay Description:Inhibition of TSPO (unknown origin) in mouse MA-10 cells assessed as increase in steroid steroidogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588821(CHEMBL5200308)
Affinity DataIC50: 400nMAssay Description:Displacement of [3H]-PK11195 from TSPO receptor in rat heart microsomes incubated for 15 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588822(CHEMBL5202023)
Affinity DataIC50: 500nMAssay Description:Displacement of [3H]-Ro54864 from TSPO receptor in rat heart microsomes incubated for 45 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50274258(2-(6,8-Dichloro-2-(4-methoxyphenyl)imidazo[1,2-a]p...)
Affinity DataEC50:  571nMAssay Description:Inhibition of TSPO (unknown origin) in mouse MA-10 cells assessed as increase in steroid steroidogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588824(CHEMBL5181685)
Affinity DataIC50: 1.70E+3nMAssay Description:Displacement of [3H]-PK11195 from TSPO receptor in rat heart microsomes incubated for 15 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588816(CHEMBL5191240)
Affinity DataEC50:  6.99E+3nMAssay Description:Inhibition of TSPO (unknown origin) in mouse MA-10 cells assessed as increase in steroid steroidogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50579426(CHEMBL330116 | CGS-13767)
Affinity DataIC50: 9.80E+3nMAssay Description:Displacement of [3H]-PK11195 from TSPO receptor in rat heart microsomes incubated for 15 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588817(CHEMBL5193551)
Affinity DataEC50:  1.59E+4nMAssay Description:Inhibition of TSPO (unknown origin) in mouse MA-10 cells assessed as increase in steroid steroidogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588819(CHEMBL5194870)
Affinity DataEC50:  2.12E+4nMAssay Description:Inhibition of TSPO (unknown origin) in mouse MA-10 cells assessed as increase in steroid steroidogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranslocator protein(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50588818(CHEMBL5174807)
Affinity DataEC50:  3.90E+4nMAssay Description:Inhibition of TSPO (unknown origin) in mouse MA-10 cells assessed as increase in steroid steroidogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed