Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50015716
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589142BDBM50589142(CHEMBL5184459)
Affinity DataIC50: 0.0190nMAssay Description:Inhibition of human recombinant c-MET in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589150BDBM50589150(CHEMBL5189340)
Affinity DataIC50: 0.0230nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589141BDBM50589141(CHEMBL5174958)
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of human recombinant c-MET in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16673BDBM16673(BAY439006 | CHEMBL1336 | BAY 43-9006 | 4-[4-({[4-c...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589147BDBM50589147(CHEMBL5186748)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589150BDBM50589150(CHEMBL5189340)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589140BDBM50589140(CHEMBL5190707)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of c-MET (unknown origin) using FAM-labelled peptide as substrate incubated for 10 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589144BDBM50589144(CHEMBL5208686)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589145BDBM50589145(CHEMBL5177149)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27566BDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human full length PARP1 expressed in Escherichia coli rosetta (DE3) incubated for 20 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589143BDBM50589143(CHEMBL5174011)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human full length PARP1 expressed in Escherichia coli rosetta (DE3) incubated for 20 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50288530BDBM50288530(CHEMBL4098253)
Affinity DataIC50: 2.80nMAssay Description:Displacement of [125I]KX1 from PARP1 in human OVCAR-8 cells incubated for 1 hr by wizard gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589154BDBM50589154(CHEMBL5176058)
Affinity DataIC50: 4.20nMAssay Description:Displacement of [125I]KX1 from PARP1 in human OVCAR-8 cells incubated for 1 hr by wizard gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589155BDBM50589155(CHEMBL5196674)
Affinity DataIC50: 4.70nMAssay Description:Displacement of [125I]KX1 from PARP1 in human OVCAR-8 cells incubated for 1 hr by wizard gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589152BDBM50589152(CHEMBL5179574)
Affinity DataIC50: 7nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589153BDBM50589153(CHEMBL5185911)
Affinity DataIC50: 8.20nMAssay Description:Displacement of [125I]KX1 from PARP1 in human OVCAR-8 cells incubated for 1 hr by wizard gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589157BDBM50589157(CHEMBL5180625)
Affinity DataIC50: 12nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589159BDBM50589159(CHEMBL5195527)
Affinity DataIC50: 16nMAssay Description:Inhibition of PARP1 (unknown origin) by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589160BDBM50589160(CHEMBL5186944)
Affinity DataIC50: 33nMAssay Description:Inhibition of BTK (unknown origin) incubated for 30 mins in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27566BDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 34nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589151BDBM50589151(CHEMBL5202615)
Affinity DataIC50: 37nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589156BDBM50589156(CHEMBL5186314)
Affinity DataIC50: 44nMAssay Description:Displacement of [125I]KX1 from PARP1 in human OVCAR-8 cells incubated for 1 hr by wizard gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589158BDBM50589158(CHEMBL5181382)
Affinity DataIC50: 46nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 30 mins by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589152BDBM50589152(CHEMBL5179574)
Affinity DataIC50: 57nMAssay Description:Inhibition of HDAC6 (unknown origin) measured after 15 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589146BDBM50589146(CHEMBL5202124)
Affinity DataIC50: 61nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536938BDBM50536938(CHEMBL4521684)
Affinity DataIC50: 97nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589163BDBM50589163(CHEMBL5181360)
Affinity DataIC50: 110nMAssay Description:Inhibition of VEGFR2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate measured after 5 mins in presence of ATP by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589164BDBM50589164(CHEMBL5204637)
Affinity DataIC50: 310nMAssay Description:Inhibition of VEGFR2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate measured after 5 mins in presence of ATP by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589162BDBM50589162(CHEMBL5208660)
Affinity DataIC50: 910nMAssay Description:Inhibition of VEGFR2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate measured after 5 mins in presence of ATP by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589148BDBM50589148(CHEMBL5187847)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589149BDBM50589149(CHEMBL5205255)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly (Glu, Tyr) substrate incubated for 40 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589161BDBM50589161(CHEMBL5187237)
Affinity DataIC50: 1.07E+5nMAssay Description:Inhibition of c-Met (unknown origin) incubated for 20 to 30 mins in presence of [33P]-ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589148BDBM50589148(CHEMBL5187847)
Affinity DataIC50: 1.15E+5nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed