Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) with all data for entry = 50012971
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM86704(CAS_93957-54-1 | Fluvastatin | cid_446155)
Affinity DataEC50:  7.10E+3nMAssay Description:Activation of recombinant SIRT6 (unknown origin) using fluoro substrate peptide incubated for 1 hr in presence of NAD by Fluor de Lys assay based flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50528216(CHEMBL4440358)
Affinity DataEC50:  1.00E+4nMAssay Description:Activation of wild type full length human SIRT6 expressed in Escherichia coli BL21(DE3) using RHKK-ac-AMC as substrate incubated for 2 hrs in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM86704(CAS_93957-54-1 | Fluvastatin | cid_446155)
Affinity DataEC50: >2.50E+5nMAssay Description:Activation of N-terminal His-tagged human SIRT6 (1 to 355 residues) expressed in Escherichia coli M15(pREP4) assessed as increase in deacetylation ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed