Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50011458
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498319(US11014911, Example 144 | US11718603, Example 144)
Affinity DataKi:  0.100nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498320(US11014911, Example 145 | US11718603, Example 145)
Affinity DataKi:  0.120nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498334(US11014911, Example 160 | US11014911, Example 159 ...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498332(US11014911, Example 158 | US11014911, Example 157 ...)
Affinity DataKi:  0.170nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498731((1S,3R)-3-(3-{[(6- methoxypyridin-3- yl)acetyl]a...)
Affinity DataKi:  0.460nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498707(US11014911, Example 532 | (1R,3S)-3-(3-{[(6- meth...)
Affinity DataKi:  0.770nMAssay Description:Inhibition of recombinant full length wild-type CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as reduction in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498332(US11014911, Example 158 | US11014911, Example 157 ...)
Affinity DataKi:  0.780nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498320(US11014911, Example 145 | US11718603, Example 145)
Affinity DataKi:  0.950nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498319(US11014911, Example 144 | US11718603, Example 144)
Affinity DataKi:  1.30nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498707(US11014911, Example 532 | (1R,3S)-3-(3-{[(6- meth...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498334(US11014911, Example 160 | US11014911, Example 159 ...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM498731((1S,3R)-3-(3-{[(6- methoxypyridin-3- yl)acetyl]a...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant GSK3beta H350L mutant expressed in baculovirus-infected Sf21 cells assessed as reduction in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed