Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50018229
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant human C-terminus His-tagged SphK1 expressed in baculovirus infected Sf21 cells using FITC-sphingosine as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407504(CHEMBL5275740)
Affinity DataKi:  40nMAssay Description:Inhibition of SphK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407504(CHEMBL5275740)
Affinity DataKi:  300nMAssay Description:Inhibition of SphK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50600(cid_282594 | N-(3-Chloro-1,4-dioxo-1,4-dihydro-nap...)
Affinity DataKi:  300nMAssay Description:Inhibition of SphK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50: 356nMAssay Description:Inhibition of recombinant human C-terminus His-tagged SphK2 expressed in baculovirus infected Sf21 cells using FITC-sphingosine as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Mouse)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407506(CHEMBL4595333)
Affinity DataKi:  400nMAssay Description:Inhibition of recombinant mouse SphK2 expressed in baculovirus infected Sf9 cells using D-erythro-sphingosine and [gamma-32P]ATP as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM4078(Elagic Acid | CHEMBL6246 | 6,7,13,14-tetrahydroxy-...)
Affinity DataIC50: 740nMAssay Description:Inhibition of SphK1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ATP as substrate preincubated for 1 hrs followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407512(CHEMBL4740910)
Affinity DataIC50: 800nMAssay Description:Inhibition of SphK1 (unknown origin) using ATP as substrate preincubated for 40 mins followed by substrate addition and measured after 5 mins by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Mouse)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407507(CHEMBL5281819)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of recombinant mouse SphK2 expressed in baculovirus infected Sf9 cells using D-erythro-sphingosine and [gamma-32P]ATP as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of recombinant human SphK2 expressed in Sf9 cells assessed as decrease in [33P]SIP production using d-erythro-sphingosine and [gamma-32P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50251394(CHEMBL1819205)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant GST-tagged SphK2 (unknown origin) (1 to 618 residues) expressed in baculovirus using sphingosine as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of SphK1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ATP as substrate preincubated for 60 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50009730(2-Amino-octadec-4-ene-1,3-diol(Sphingosine) | CHEM...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of SphK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407508(CHEMBL5274862)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant SphK1 (unknown origin) using NBD-sphingosine as substrate in presence of ATP by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407513(CHEMBL5283022)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of SphK2 (unknown origin) using ATP as substrate preincubated for 40 mins followed by substrate addition and measured after 5 mins by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407511(2-EPI JASPINE B)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of SphK1 (unknown origin) using ATP as substrate preincubated for 40 mins followed by substrate addition and measured after 5 mins by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407510(PACHASTRISSAMINE | Pachastrissamine)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of SphK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407505(CHEMBL447685)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of SphK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50251394(CHEMBL1819205)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of recombinant GST-tagged SphK1 (unknown origin) (1 to 384 residues) expressed in baculovirus using sphingosine as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407510(PACHASTRISSAMINE | Pachastrissamine)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of SphK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50139649(CHEMBL3764617)
Affinity DataKi:  6.90E+3nMAssay Description:Inhibition of recombinant human SphK2 expressed in baculovirus infected Sf9 cells using d-erythro-sphingosine and [gamma-32P]ATP as substrate by liqu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50312869(N-aryl-4-aryl-1,3-thiazole-2-amine, 5 | CHEMBL1076...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of SphK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50393642(CHEMBL2158685)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of SphK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407505(CHEMBL447685)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of SphK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of recombinant human SphK1 expressed in Sf9 cells assessed as decrease in [33P]SIP production using d-erythro-sphingosine and [gamma-32P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50312869(N-aryl-4-aryl-1,3-thiazole-2-amine, 5 | CHEMBL1076...)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of SphK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Mouse)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407506(CHEMBL4595333)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of recombinant mouse SphK1 expressed in baculovirus infected Sf9 cells using D-erythro-sphingosine and [gamma-32P]ATP as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Mouse)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407507(CHEMBL5281819)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of recombinant mouse SphK1 expressed in baculovirus infected Sf9 cells using D-erythro-sphingosine and [gamma-32P]ATP as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407511(2-EPI JASPINE B)
Affinity DataIC50: 2.48E+4nMAssay Description:Inhibition of SphK2 (unknown origin) using ATP as substrate preincubated for 40 mins followed by substrate addition and measured after 5 mins by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50139649(CHEMBL3764617)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of recombinant human SphK1 expressed in baculovirus infected Sf9 cells using d-erythro-sphingosine and [gamma-32P]ATP as substrate by liqu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407513(CHEMBL5283022)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of SphK1 (unknown origin) using ATP as substrate preincubated for 40 mins followed by substrate addition and measured after 5 mins by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407509(CHEMBL5278394)
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of recombinant SphK2 (unknown origin) using NBD-sphingosine as substrate in presence of ATP by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407509(CHEMBL5278394)
Affinity DataIC50: 6.50E+5nMAssay Description:Inhibition of recombinant SphK1 (unknown origin) using NBD-sphingosine as substrate in presence of ATP by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed