Compile Data Set for Download or QSAR
Report error Found 182 Enz. Inhib. hit(s) with all data for entry = 50013577
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM363689(US9850277, Compound 176 | US10682352, Compound AG1...)
Affinity DataEC50:  12nMAssay Description:Inhibition of C-terminal NanoLuc 86b-tagged IDH1 R132H (unknown origin) expressed in HEK293T cells assessed as increase in thermal stability by measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50503248(CHEMBL4448475)
Affinity DataEC50:  13nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) expressed in human U87 cells assessed as R-2-hydroxyglutarate production after 48 hrs by LC-MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50503248(CHEMBL4448475)
Affinity DataEC50:  13nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) expressed in human U87 cells assessed as R-2-hydroxyglutarate production after 48 hrs by LC-MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM363689(US9850277, Compound 176 | US10682352, Compound AG1...)
Affinity DataEC50:  27nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) expressed in human U87 cells assessed as R-2-hydroxyglutarate production after 48 hrs by LC-MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567821(CHEMBL4875277)
Affinity DataIC50: 35nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567821(CHEMBL4875277)
Affinity DataIC50: 39nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567816(CHEMBL4851708)
Affinity DataIC50: 39nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567825(CHEMBL4861426)
Affinity DataIC50: 42nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567833(CHEMBL4868649)
Affinity DataIC50: 44nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567808(CHEMBL4860083)
Affinity DataIC50: 44nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567815(CHEMBL4864243)
Affinity DataIC50: 44nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567832(CHEMBL4878489)
Affinity DataIC50: 44nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567815(CHEMBL4864243)
Affinity DataIC50: 46nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567828(CHEMBL4854924)
Affinity DataIC50: 47nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567819(CHEMBL4845768)
Affinity DataIC50: 48nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567820(CHEMBL4858156)
Affinity DataIC50: 49nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567809(CHEMBL4848154)
Affinity DataIC50: 49nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567816(CHEMBL4851708)
Affinity DataIC50: 53nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567832(CHEMBL4878489)
Affinity DataIC50: 55nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567824(CHEMBL4879014)
Affinity DataIC50: 55nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567809(CHEMBL4848154)
Affinity DataIC50: 55nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567823(CHEMBL4872718)
Affinity DataIC50: 56nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567830(CHEMBL4878829)
Affinity DataIC50: 56nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567808(CHEMBL4860083)
Affinity DataIC50: 58nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567820(CHEMBL4858156)
Affinity DataIC50: 60nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567827(CHEMBL4873139)
Affinity DataIC50: 60nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567828(CHEMBL4854924)
Affinity DataIC50: 62nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM363689(US9850277, Compound 176 | US10682352, Compound AG1...)
Affinity DataIC50: 63nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567782(CHEMBL4857251)
Affinity DataIC50: 64nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567824(CHEMBL4879014)
Affinity DataIC50: 64nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567826(CHEMBL4872262)
Affinity DataIC50: 64nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM363689(US9850277, Compound 176 | US10682352, Compound AG1...)
Affinity DataIC50: 65nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567817(CHEMBL4853810)
Affinity DataIC50: 72nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50503248(CHEMBL4448475)
Affinity DataIC50: 72nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567834(CHEMBL4851468)
Affinity DataIC50: 75nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567805(CHEMBL4867078)
Affinity DataIC50: 75nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567834(CHEMBL4851468)
Affinity DataIC50: 75nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567812(CHEMBL4864581)
Affinity DataIC50: 75nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567819(CHEMBL4845768)
Affinity DataIC50: 78nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50503248(CHEMBL4448475)
Affinity DataIC50: 81nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567818(CHEMBL4863979)
Affinity DataIC50: 82nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567825(CHEMBL4861426)
Affinity DataIC50: 94nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567827(CHEMBL4873139)
Affinity DataIC50: 94nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567817(CHEMBL4853810)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50503248(CHEMBL4448475)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567805(CHEMBL4867078)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50503248(CHEMBL4448475)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567833(CHEMBL4868649)
Affinity DataIC50: 110nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567807(CHEMBL4864789)
Affinity DataIC50: 110nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50567834(CHEMBL4851468)
Affinity DataIC50: 114nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
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