Compile Data Set for Download or QSAR
Report error Found 162 Enz. Inhib. hit(s) with all data for entry = 50014741
LigandChemical structure of BindingDB Monomer ID 50579665BDBM50579665(CHEMBL5082066)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579666BDBM50579666(CHEMBL5081964)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489281BDBM489281(US10961236, Example 54 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579667BDBM50579667(CHEMBL5090799)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489247BDBM489247(US10961236, Example 20 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579668BDBM50579668(CHEMBL5091438)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489248BDBM489248(US10961236, Example 21 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579671BDBM50579671(CHEMBL5090959)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50512861BDBM50512861(CHEMBL4558527)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489261BDBM489261(US10961236, Example 34 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50274638BDBM50274638(CHEMBL4126156 | US10858355, Example 4)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50274649BDBM50274649(CHEMBL4129600 | US10858355, Example 30)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 474028BDBM474028(N-(5-{7-[(3-Cyanophenyl)sulfamoyl]-2-[(1S)-1-cyclo...)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579651BDBM50579651(CHEMBL5089229)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489268BDBM489268(US10961236, Example 41 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579659BDBM50579659(CHEMBL5088848)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579663BDBM50579663(CHEMBL5087061)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579668BDBM50579668(CHEMBL5091438)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579667BDBM50579667(CHEMBL5090799)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50512861BDBM50512861(CHEMBL4558527)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579668BDBM50579668(CHEMBL5091438)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of PIK3C2B (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489240BDBM489240(US10961236, Example 13 | N-{6-[(5-{2-[(1S)-1-Cyclo...)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489229BDBM489229(US10961236, Example 3 | N-{6-[(5-{2-[(1S)-1-Cyclop...)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489259BDBM489259(US10961236, Example 32 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489240BDBM489240(US10961236, Example 13 | N-{6-[(5-{2-[(1S)-1-Cyclo...)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489231BDBM489231(US10961236, Example 5 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489247BDBM489247(US10961236, Example 20 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489246BDBM489246(US10961236, Example 19 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489248BDBM489248(US10961236, Example 21 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579649BDBM50579649(CHEMBL5080534)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489234BDBM489234(US10961236, Example 7 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489258BDBM489258(US10961236, Example 31 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579656BDBM50579656(CHEMBL5084078)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579664BDBM50579664(CHEMBL5081634)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kdelta in anti-IgM-stimulated human JeKo-1 cells assessed as inhibition of AKT phosphorylation at Ser473 residue incubated for 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579657BDBM50579657(CHEMBL5090934)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579658BDBM50579658(CHEMBL5091652)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579664BDBM50579664(CHEMBL5081634)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579667BDBM50579667(CHEMBL5090799)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489240BDBM489240(US10961236, Example 13 | N-{6-[(5-{2-[(1S)-1-Cyclo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489259BDBM489259(US10961236, Example 32 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579669BDBM50579669(CHEMBL5084355)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489258BDBM489258(US10961236, Example 31 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PIK3C2B (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579670BDBM50579670(CHEMBL5078135)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489231BDBM489231(US10961236, Example 5 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489228BDBM489228(US10961236, Example 2 | N-{6-[(5-{2-[(1S)-1-Cyclop...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489246BDBM489246(US10961236, Example 19 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489234BDBM489234(US10961236, Example 7 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489258BDBM489258(US10961236, Example 31 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489230BDBM489230(US10961236, Example 4 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 489235BDBM489235(US10961236, Example 8 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
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