Compile Data Set for Download or QSAR
maximum 50k data
Found 64 Enz. Inhib. hit(s) with all data for entry = 50017404
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50252729((2''Z-3''E)-6-Bromoindirubin-3''-(O-{2-[4-(2-hydro...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50:  3nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564368(CHEMBL4781746)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Sus scrofa)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50:  5nMAssay Description:Inhibition of porcine brain GSK-3alpha/beta incubated for 30 mins in presence of [33p]-gamma ATP by scintillation counter analysisMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50546117(CHEMBL4763626)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM559439(US11370779, Compound 7)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant Lyn (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant c-Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant Tyk2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant Hck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Sus scrofa)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  22nMAssay Description:Inhibition of porcine brain GSK-3alpha/beta incubated for 30 mins in presence of [33p]-gamma ATP by scintillation counter analysisMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  22nMAssay Description:Inhibition of GSK3beta (unknown origin) assessed as decrease in tau phosphorylation at Ser214 residue incubated for 30 mins by Western blot assayMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50593898(CHEMBL1208600)
Affinity DataIC50:  35nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50593898(CHEMBL1208600)
Affinity DataIC50:  65nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  79nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50:  83nMAssay Description:Inhibition of GST-fused CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  100nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
TargetAurora kinase C(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50601615(CHEMBL3265229)
Affinity DataIC50:  100nMAssay Description:Inhibition of Aurora C (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  100nMAssay Description:Inhibition of Aurora C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  100nMAssay Description:Inhibition of GST-fused CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  101nMAssay Description:Inhibition of recombinant FLT3 D835Y mutant (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  101nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  190nMAssay Description:Inhibition of GSK3beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50546117(CHEMBL4763626)
Affinity DataIC50:  222nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50:  239nMAssay Description:Inhibition of c-met (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50593898(CHEMBL1208600)
Affinity DataIC50:  300nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  300nMAssay Description:Inhibition of LCK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50601613(CHEMBL5186063)
Affinity DataIC50:  370nMAssay Description:Inhibition of Aurora A (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  380nMAssay Description:Inhibition of SGK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50005337(CHEMBL1276317)
Affinity DataIC50:  430nMAssay Description:Inhibition of recombinant c-Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  440nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50:  523nMAssay Description:Inhibition of recombinant JAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  590nMAssay Description:Inhibition of GST-fused human CDK2/cyclin A expressed in Escherichia coli using histone H1 as substrate in presence of [33p]-gamma ATP and MgATPMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50:  690nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50005337(CHEMBL1276317)
Affinity DataIC50:  950nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50005337(CHEMBL1276317)
Affinity DataIC50:  950nMAssay Description:Inhibition of c-SRC in human MDA-MB-468 cells in presence of [gamma-32P]ATP and ATP by immunoprecipitation methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Sus scrofa)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of porcine brain GSK-3alpha/beta incubated for 30 mins in presence of [33p]-gamma ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50601610(CHEMBL5194837)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant GST-fused PDK1 expressed in Sf9 cells incubated for 30 mins in presence of [gamma-33P]ATP by scintillation counter an...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM559434(US11370779, Compound 1)
Affinity DataIC50:  3.19E+3nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  3.33E+3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM559439(US11370779, Compound 7)
Affinity DataIC50:  7.89E+3nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50601615(CHEMBL3265229)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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