Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50016829
TargetTransporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22417(LY 94939 | Nisoxetine Inhibitor | Nisoxetine | LY1...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTransporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50021246(3-(3,3-dimethyl-1-phenyl-1,3-dihydroisobenzofuran-...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTransporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50597616(CHEMBL5188712)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTransporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50597616(CHEMBL5188712)
Affinity DataKi:  785nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50021246(3-(3,3-dimethyl-1-phenyl-1,3-dihydroisobenzofuran-...)
Affinity DataKi:  795nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50597618(CHEMBL5176356)
Affinity DataKi:  964nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50597618(CHEMBL5176356)
Affinity DataKi:  1.14E+3nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50597616(CHEMBL5188712)
Affinity DataKi:  1.54E+3nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50597617(CHEMBL5170876)
Affinity DataKi:  4.87E+3nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50597617(CHEMBL5170876)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTransporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50597617(CHEMBL5170876)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTransporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50597618(CHEMBL5176356)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50021246(3-(3,3-dimethyl-1-phenyl-1,3-dihydroisobenzofuran-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed