Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50015734
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 77970BDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 112774BDBM112774(US8629135, SW-01)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 112777BDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50101973BDBM50101973(CHEBI:6690 | BA-34276 [As Hydrochloride] | Maproti...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 35229BDBM35229(Desmethylimipramine | 3-(10,11-dihydro-5H-dibenzo[...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240410BDBM50240410(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50020712BDBM50020712(CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50176062BDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017696BDBM50017696(N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamin...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 112780BDBM112780(US8629135, SW-07)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010859BDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50170636BDBM50170636(2-[4-(3-Dibenzo[b,f]azepin-5-yl-propyl)-piperazin-...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50101813BDBM50101813(CHEBI:31399 | Cilnidipine)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22870BDBM22870(CHEMBL1113 | Asendin | 2-chloro-11-piperazin-1-yld...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed