Compile Data Set for Download or QSAR
Report error Found 76 Enz. Inhib. hit(s) with all data for entry = 50016985
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357737BDBM357737(KM-05-166/(I-206) | US10214530, Example 24)
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357735BDBM357735(KM-05-193/(I-209) | US10214530, Example 27)
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357739BDBM357739(AG-01-128/(I-202) | US10214530, Example 18)
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357736BDBM357736(MW-01-157/(I-207) | US10214530, Example 25)
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598895BDBM50598895(CHEMBL5172829)
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598894BDBM50598894(CHEMBL5197055)
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357741BDBM357741(MW-01-153/(I-47) | US10214530, Example 53)
Affinity DataIC50: 43nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357743BDBM357743(MW-01-139/(I-46) | US10214530, Example 52)
Affinity DataIC50: 47nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598896BDBM50598896(CHEMBL5176333)
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357740BDBM357740(KM-05-139/(I-23) | US10214530, Example 23)
Affinity DataIC50: 51nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598897BDBM50598897(CHEMBL5174736)
Affinity DataIC50: 60nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357738BDBM357738(KM-05-130/(I-19) | US10214530, Example 19)
Affinity DataIC50: 60nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357744BDBM357744(KM-05-80/(I-1) | US10214530, Example 1)
Affinity DataIC50: 70nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357745BDBM357745(KM-05-125/(I-13) | US10214530, Example 13)
Affinity DataIC50: 70nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357748BDBM357748(KM-05-89/(I-2) | US10214530, Example 2)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357750BDBM357750(KM-05-135/(I-15) | US10214530, Example 15)
Affinity DataIC50: 140nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357751BDBM357751(KM-05-128/(I-17) | US10214530, Example 17)
Affinity DataIC50: 140nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357760BDBM357760(KM-05-50/(I-4) | US10214530, Example 4)
Affinity DataIC50: 170nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357754BDBM357754(KM-05-60/(I-10) | US10214530, Example 10)
Affinity DataIC50: 170nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357752BDBM357752(KM-05-126/(I-12) | US10214530, Example 12)
Affinity DataIC50: 230nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357756BDBM357756(KM480/(I-41) | US10214530, Example 47)
Affinity DataIC50: 230nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598894BDBM50598894(CHEMBL5197055)
Affinity DataIC50: 240nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357735BDBM357735(KM-05-193/(I-209) | US10214530, Example 27)
Affinity DataIC50: 300nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357736BDBM357736(MW-01-157/(I-207) | US10214530, Example 25)
Affinity DataIC50: 350nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357737BDBM357737(KM-05-166/(I-206) | US10214530, Example 24)
Affinity DataIC50: 360nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357738BDBM357738(KM-05-130/(I-19) | US10214530, Example 19)
Affinity DataIC50: 410nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357739BDBM357739(AG-01-128/(I-202) | US10214530, Example 18)
Affinity DataIC50: 430nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357759BDBM357759(KM-05-127/(I-16) | US10214530, Example 16)
Affinity DataIC50: 450nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357769BDBM357769(KM446/(I-35) | US10214530, Example 41)
Affinity DataIC50: 490nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357762BDBM357762(KM430/(I-31) | US10214530, Example 37)
Affinity DataIC50: 490nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357740BDBM357740(KM-05-139/(I-23) | US10214530, Example 23)
Affinity DataIC50: 590nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357761BDBM357761(KM-05-55 Fr10-12/(l-6) | US10214530, Example 6)
Affinity DataIC50: 690nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357741BDBM357741(MW-01-153/(I-47) | US10214530, Example 53)
Affinity DataIC50: 700nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50145648BDBM50145648(Xermelo | LX1032 | LX1606 | LP-778902 | Telotrista...)
Affinity DataIC50: 710nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598893BDBM50598893(CHEMBL5170266)
Affinity DataIC50: 760nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50145648BDBM50145648(Xermelo | LX1032 | LX1606 | LP-778902 | Telotrista...)
Affinity DataIC50: 770nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357763BDBM357763(KM-05-16/(I-3) | US10214530, Example 3)
Affinity DataIC50: 820nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357743BDBM357743(MW-01-139/(I-46) | US10214530, Example 52)
Affinity DataIC50: 820nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357766BDBM357766(KM477/(I-40) | US10214530, Example 46)
Affinity DataIC50: 830nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598895BDBM50598895(CHEMBL5172829)
Affinity DataIC50: 850nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357744BDBM357744(KM-05-80/(I-1) | US10214530, Example 1)
Affinity DataIC50: 850nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357764BDBM357764(KM406/(I-24) | US10214530, Example 30)
Affinity DataIC50: 920nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357745BDBM357745(KM-05-125/(I-13) | US10214530, Example 13)
Affinity DataIC50: 960nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598896BDBM50598896(CHEMBL5176333)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357776BDBM357776(KM483/(I-42) | US10214530, Example 48)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357748BDBM357748(KM-05-89/(I-2) | US10214530, Example 2)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357774BDBM357774(KM448/(I-37) | US10214530, Example 43)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357750BDBM357750(KM-05-135/(I-15) | US10214530, Example 15)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357751BDBM357751(KM-05-128/(I-17) | US10214530, Example 17)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357752BDBM357752(KM-05-126/(I-12) | US10214530, Example 12)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
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