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Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50019909
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 340nMAssay Description:Inhibition of ABCG2 (unknown origin) transfected in HEK293 cell membrane vesicle assessed as inhibition of 14C-uric acid uptake incubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 530nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624544(CHEMBL5439993)
Affinity DataIC50: 800nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624541(CHEMBL5400167)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624545(CHEMBL5405072)
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624558(CHEMBL5396194)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624550(CHEMBL5429502)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624559(CHEMBL5395589)
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624549(CHEMBL5417202)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624542(CHEMBL5437905)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624554(CHEMBL5412709)
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibition of OAT1 (unknown origin) transfected in HEK293 cells assessed as inhibition of 6-CFL uptake preincubated for 30 mins followed by 6-CFL add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624543(CHEMBL5397658)
Affinity DataIC50: 2.26E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624551(CHEMBL5405794)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624547(CHEMBL5438015)
Affinity DataIC50: 2.36E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624557(CHEMBL5417306)
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624552(CHEMBL5436610)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624548(CHEMBL5435294)
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624560(CHEMBL5421730)
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624546(CHEMBL5437838)
Affinity DataIC50: 3.22E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624556(CHEMBL5396907)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624544(CHEMBL5439993)
Affinity DataIC50: 4.04E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) transfected in HEK293 cell membrane vesicle assessed as inhibition of 14C-uric acid uptake incubated for 15 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624553(CHEMBL5394644)
Affinity DataIC50: 4.85E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624555(CHEMBL5426916)
Affinity DataIC50: 5.83E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)
Affinity DataIC50: 7.56E+3nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624544(CHEMBL5439993)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of OAT1 (unknown origin) transfected in HEK293 cells assessed as inhibition of 6-CFL uptake preincubated for 30 mins followed by 6-CFL add...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 2, facilitated glucose transporter member 9(Mus musculus)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of mouse GLUT9 transfected in human HEK293 cells assessed as inhibition of uric acid induced current by cell patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 2, facilitated glucose transporter member 9(Mus musculus)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50624544(CHEMBL5439993)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of mouse GLUT9 transfected in human HEK293 cells assessed as inhibition of uric acid induced current by cell patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed