Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50019329
TargetBile acid receptor(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50618160(CHEMBL5400252)
Affinity DataEC50:  30nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR ligand binding domain assessed as biotinylated Src1 peptide recruitment incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50618162(CHEMBL5399923)
Affinity DataEC50:  80nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR ligand binding domain assessed as biotinylated Src1 peptide recruitment incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR ligand binding domain assessed as biotinylated Src1 peptide recruitment incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50618160(CHEMBL5400252)
Affinity DataEC50:  680nMAssay Description:Agonist activity at TGR5 receptor in human NCI-H716 cells assessed as activation of intracellular cAMP production incubated for 1 hr by HTR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at TGR5 receptor in human NCI-H716 cells assessed as activation of intracellular cAMP production incubated for 1 hr by HTR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled bile acid receptor 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50028027(CHEMBL3342086)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at TGR5 receptor in human NCI-H716 cells assessed as activation of intracellular cAMP production incubated for 1 hr by HTR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50028027(CHEMBL3342086)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR ligand binding domain assessed as biotinylated Src1 peptide recruitment incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50618162(CHEMBL5399923)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at TGR5 receptor in human NCI-H716 cells assessed as activation of intracellular cAMP production incubated for 1 hr by HTR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50618161(CHEMBL5429160)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR ligand binding domain assessed as biotinylated Src1 peptide recruitment incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  1.40E+4nMAssay Description:Agonist activity at TGR5 receptor in human NCI-H716 cells assessed as activation of intracellular cAMP production incubated for 1 hr by HTR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50618163(CHEMBL5417003)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 receptor in human NCI-H716 cells assessed as activation of intracellular cAMP production incubated for 1 hr by HTR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR ligand binding domain assessed as biotinylated Src1 peptide recruitment incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50618163(CHEMBL5417003)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR ligand binding domain assessed as biotinylated Src1 peptide recruitment incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50618161(CHEMBL5429160)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 receptor in human NCI-H716 cells assessed as activation of intracellular cAMP production incubated for 1 hr by HTR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed