Found 23 Enz. Inhib. hit(s) with all data for entry = 50016189 TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant CYP17A1 incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
3D Structure (crystal)TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant CYP17A1 incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Antagonist activity at androgen receptor T877A mutant (unknown origin) expressed in HEK293 cells incubated for 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 209nMAssay Description:Antagonist activity at androgen receptor T877A mutant (unknown origin) expressed in HEK293 cells incubated for 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 244nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
Affinity DataIC50: 247nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
Affinity DataIC50: 268nMAssay Description:Antagonist activity at androgen receptor F876L mutant (unknown origin) expressed in HEK293 cells incubated for 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 492nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
Affinity DataIC50: 511nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
Affinity DataIC50: 915nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
Affinity DataIC50: 981nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
Affinity DataIC50: 1.11E+3nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+3nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+3nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+3nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
Affinity DataIC50: 1.64E+3nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 2.59E+3nMAssay Description:Inhibition of human recombinant CYP17A1 incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human recombinant CYP17A1 incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human recombinant CYP17A1 incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human recombinant CYP17A1 incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 4.99E+3nMAssay Description:Inhibition of hERG potassium channel at -80 mV holding potential incubated for 3 mins by automated patch clamp methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 6.47E+3nMAssay Description:Inhibition of hERG potassium channel at -80 mV holding potential incubated for 3 mins by automated patch clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 9.15E+3nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
