Compile Data Set for Download or QSAR
Report error Found 85 Enz. Inhib. hit(s) with all data for entry = 50015983
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(Apilimod | Sta-5326 | STA 5326 | STA-5326 | APILIM...)
Affinity DataKd:  0.0750nMAssay Description:Binding affinity to human wild type partial length PIKFYVE (F1512 to C2098 residues) mammalian expression assessed as dissociation constant by Kinome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(Apilimod | Sta-5326 | STA 5326 | STA-5326 | APILIM...)
Affinity DataIC50: 0.309nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(Apilimod | Sta-5326 | STA 5326 | STA-5326 | APILIM...)
Affinity DataIC50: 0.312nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590929(CHEMBL4303292 | US20240016810, Compound TABLE 16.2...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590929(CHEMBL4303292 | US20240016810, Compound TABLE 16.2...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590943(CHEMBL5189479)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590942(CHEMBL5193848)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human wild type partial length PIKfyve (F1512 to C2098 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(Apilimod | Sta-5326 | STA 5326 | STA-5326 | APILIM...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590929(CHEMBL4303292 | US20240016810, Compound TABLE 16.2...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590939(CHEMBL5174830)
Affinity DataIC50: 4nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590939(CHEMBL5174830)
Affinity DataIC50: 4nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590956(CHEMBL5171359)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590931(CHEMBL5181163)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590941(CHEMBL5198944)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590939(CHEMBL5174830)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590934(CHEMBL5207387)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590935(CHEMBL5171753)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590942(CHEMBL5193848)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590935(CHEMBL5171753)
Affinity DataIC50: 11nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590935(CHEMBL5171753)
Affinity DataIC50: 11nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590943(CHEMBL5189479)
Affinity DataIC50: 13nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590943(CHEMBL5189479)
Affinity DataIC50: 13nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 14nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase TAO1(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 20nMAssay Description:Inhibition of human wild type TAOK1 (M1 to A320 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590931(CHEMBL5181163)
Affinity DataIC50: 21nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590932(CHEMBL5190524)
Affinity DataIC50: 22nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590937(CHEMBL5188159)
Affinity DataIC50: 26nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 33nMAssay Description:Inhibition of PIKFYVE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590936(CHEMBL5200109)
Affinity DataIC50: 34nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590957(CHEMBL5185288)
Affinity DataIC50: 40nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase TAO3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 45nMAssay Description:Inhibition of human wild type partial length TAOK3 (M1 to T316 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590952(CHEMBL5190153)
Affinity DataIC50: 46nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 6(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 60nMAssay Description:Inhibition of human wild type partial length PAK6 (N298 to C681 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590930(CHEMBL5202422)
Affinity DataIC50: 61nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 74nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 74nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590945(CHEMBL5190724)
Affinity DataIC50: 75nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590938(CHEMBL5192827)
Affinity DataIC50: 77nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase TAO2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 89nMAssay Description:Inhibition of human wild type partial length TAOK2 (M1 to A320 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetTestis-specific serine/threonine-protein kinase 3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 91nMAssay Description:Inhibition of wild-type human full length TSSK3 (M1 to T268 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 5(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 96nMAssay Description:Inhibition of human wild type partial length PAK5 (Y400 to H719 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 110nMAssay Description:Inhibition of human wild type partial length PAK4 (Q144 to R438 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590954(CHEMBL5187698)
Affinity DataIC50: 123nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590940(CHEMBL5184182)
Affinity DataIC50: 140nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetTestis-specific serine/threonine-protein kinase 1(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 210nMAssay Description:Inhibition of human wild type TSSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590948(CHEMBL5194568)
Affinity DataIC50: 220nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590939(CHEMBL5174830)
Affinity DataIC50: 265nMAssay Description:Inhibition of MYLK in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
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