Found 45 Enz. Inhib. hit(s) with all data for entry = 50015837 TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 88nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Time-dependent inhibition of CYP3A4 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Time-dependent inhibition of CYP2D6 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition by LC...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Time-dependent inhibition of CYP2D6 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition by LC...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 6.50E+3nMAssay Description:Time-dependent inhibition of CYP2C9 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 8.70E+3nMAssay Description:Time-dependent inhibition of CYP2D6 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.24E+4nMAssay Description:Time-dependent inhibition of CYP2C9 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:Time-dependent inhibition of CYP2C8 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.43E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes at 10 uM using amodiaquine as substrate preincubated for 10 mins followed by NADPH addition by LC/MS a...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.46E+4nMAssay Description:Time-dependent inhibition of CYP2C9 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition by LC...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.54E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.58E+4nMAssay Description:Time-dependent inhibition of CYP3A4 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 2.21E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 10 mins followed by NADPH addition by LC/MS ana...More data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 3.87E+4nMAssay Description:Time-dependent inhibition of CYP2C8 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 3.91E+4nMAssay Description:Time-dependent inhibition of CYP2C8 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 4.33E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes at 10 uM using amodiaquine as substrate preincubated for 10 mins followed by NADPH addition by LC/MS a...More data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 4.52E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes at 10 uM using amodiaquine as substrate preincubated for 10 mins followed by NADPH addition by LC/MS a...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 5.43E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 10 mins followed by NADPH addition by LC/MS ana...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Time-dependent inhibition of CYP3A4 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 10 mins followed by NADPH addition by LC/MS ana...More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Wuhan University Of Science And Technology
Curated by ChEMBL
Wuhan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
