Compile Data Set for Download or QSAR
Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 50020123
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50531908(US10676469, Compound 142 | Btrx-335140 | CYM-53093...)
Affinity DataEC50:  4.59E+3nMAssay Description:Agonist activity at MOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50159165(2S,4aR,6a(R,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataEC50:  2.20nMAssay Description:Displacement of [35S]GTPgammaS binding from human KOR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626414(CHEMBL5431513)
Affinity DataKi:  0.00600nMAssay Description:Binding affinity to wild type human KOR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626414(CHEMBL5431513)
Affinity DataKi:  0.0210nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626416(CHEMBL5405541)
Affinity DataKi:  0.0730nMAssay Description:Binding affinity to human MOR expressed in HEK293 cells assessed as inhibition constant by GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626414(CHEMBL5431513)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity to human DOR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626412(CHEMBL5426627)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626416(CHEMBL5405541)
Affinity DataKi:  0.130nMAssay Description:Binding affinity human DOR expressed in CHO cells assessed as inhibition constant by radio ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50017233(LEVO-DROMORAN | CHEMBL592 | LEVORPHANOL)
Affinity DataKi:  0.210nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626411(CHEMBL5418013)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM21130(U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626416(CHEMBL5405541)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to wild type human KOR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626413(CHEMBL5428706)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50097580((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50097580((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.420nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626410(CHEMBL5395105)
Affinity DataKi: <1nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626418(CHEMBL5419132)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human KOR expressed in HEK293 cells assessed as inhibition constant incubated for 90 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518021(CHEMBL610279)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human KOR receptor stably expressed in HEK293 cells assessed as inhibition constant by GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50017233(LEVO-DROMORAN | CHEMBL592 | LEVORPHANOL)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518022(CHEMBL4458783)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626407(CHEMBL5402380)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50032403((pentazocine)2-{4-[(2,4-Diamino-pteridin-6-ylmethy...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50035131((1S,9S,13S)-1,13-dimethyl-10-(3-methylbut-2-enyl)-...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626408(CHEMBL5401204)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626408(CHEMBL5401204)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50159165(2S,4aR,6a(R,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataKi:  4nMAssay Description:Binding affinity to KOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50017233(LEVO-DROMORAN | CHEMBL592 | LEVORPHANOL)
Affinity DataKi:  4.20nMAssay Description:Binding affinity to human DOR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50159165(2S,4aR,6a(R,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity to KOR in Guinea pig brain assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50097580((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  4.90nMAssay Description:Binding affinity to human DOR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50366356(EMD-61753 | ASIMADOLINE HYDROCHLORIDE)
Affinity DataKi:  5.60nMAssay Description:Binding affinity to human recombinant KOR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50032403((pentazocine)2-{4-[(2,4-Diamino-pteridin-6-ylmethy...)
Affinity DataKi:  7.60nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50035131((1S,9S,13S)-1,13-dimethyl-10-(3-methylbut-2-enyl)-...)
Affinity DataKi:  7.60nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626415(Spiradoline | Espiradolina | SPIRADOLINE)
Affinity DataKi:  8.60nMAssay Description:Binding affinity to KOR receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626417(CHEMBL5414016)
Affinity DataKi:  9nMAssay Description:Binding affinity to wild type human KOR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626418(CHEMBL5419132)
Affinity DataKi: >10nMAssay Description:Binding affinity to human KOR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50278337(Naltrexone methiodide | CHEMBL470617)
Affinity DataKi:  10nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626418(CHEMBL5419132)
Affinity DataKi: >10nMAssay Description:Binding affinity to human DOR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50399885(CHEMBL2180640)
Affinity DataKi:  11nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50159165(2S,4aR,6a(R,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataKi:  16nMAssay Description:Binding affinity to KOR (unknown origin) expressed in HEK293 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518021(CHEMBL610279)
Affinity DataKi:  20nMAssay Description:Binding affinity to human MOR expressed in HEK293 cells assessed as inhibition constant by GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50159165(2S,4aR,6a(R,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataKi:  40nMAssay Description:Binding affinity to wild type human KOR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626409(CHEMBL5406584)
Affinity DataKi:  50nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50035131((1S,9S,13S)-1,13-dimethyl-10-(3-methylbut-2-enyl)-...)
Affinity DataKi:  62nMAssay Description:Binding affinity to DOR (unknown origin) assessed as inhibition constant by ratio ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50032403((pentazocine)2-{4-[(2,4-Diamino-pteridin-6-ylmethy...)
Affinity DataKi:  62nMAssay Description:Binding affinity to DOR (unknown origin) assessed as inhibition constant by ratio ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518021(CHEMBL610279)
Affinity DataKi:  82nMAssay Description:Binding affinity to human DOR expressed in HEK293 cells assessed as inhibition constant by GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50399885(CHEMBL2180640)
Affinity DataKi:  360nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  370nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626409(CHEMBL5406584)
Affinity DataKi:  538nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50626408(CHEMBL5401204)
Affinity DataKi:  722nMAssay Description:Binding affinity to human DOR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518022(CHEMBL4458783)
Affinity DataKi:  1.90E+3nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
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