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Found 13 Enz. Inhib. hit(s) with all data for entry = 50018039
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50593633(ARQ 092 | ARQ 092 FREE BASE | ARQ-092 | Arq-092 | ...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of AKT1 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50593633(ARQ 092 | ARQ 092 FREE BASE | ARQ-092 | Arq-092 | ...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of AKT2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50593633(ARQ 092 | ARQ 092 FREE BASE | ARQ-092 | Arq-092 | ...)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of AKT3 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50607141(CHEMBL5220876)
Affinity DataIC50:  86nMAssay Description:Inhibition of AKT2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50607140(CHEMBL5221128)
Affinity DataIC50:  90nMAssay Description:Inhibition of AKT2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50607141(CHEMBL5220876)
Affinity DataIC50:  407nMAssay Description:Inhibition of AKT3 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50607140(CHEMBL5221128)
Affinity DataIC50:  544nMAssay Description:Inhibition of AKT3 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50607142(CHEMBL5220918)
Affinity DataIC50:  558nMAssay Description:Inhibition of AKT2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50607141(CHEMBL5220876)
Affinity DataIC50:  684nMAssay Description:Inhibition of AKT1 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50607140(CHEMBL5221128)
Affinity DataIC50:  798nMAssay Description:Inhibition of AKT1 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50607142(CHEMBL5220918)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of AKT1 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50607142(CHEMBL5220918)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of AKT3 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 120 mins by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50607140(CHEMBL5221128)
Affinity DataEC50:  23nMAssay Description:Induction of AKT degradation in MS21-resistant human SW620 cells harboring KRAS/BRAF mutant assessed as reduction in total AKT level incubated for 24...More data for this Ligand-Target Pair
In DepthDetails PubMed