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Found 19 Enz. Inhib. hit(s) with all data for entry = 50018681
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50611346(CHEMBL5266070)
Affinity DataIC50:  22nMAssay Description:Binding affinity to BRD4 bromodomain 1 in human Ramos cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50611350(CHEMBL5272010)
Affinity DataIC50:  240nMAssay Description:Induction of BRD4 degradation in human 231MFP cellsMore data for this Ligand-Target Pair
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TargetE3 ubiquitin-protein ligase RNF114(Homo sapiens)TBA
LigandPNGBDBM50611351(CHEMBL5274261)
Affinity DataIC50:  470nMAssay Description:Inhibition of RNF114 (unknown origin)More data for this Ligand-Target Pair
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TargetFolliculin-interacting protein 1(Homo sapiens)TBA
LigandPNGBDBM50611352(CHEMBL5289726)
Affinity DataIC50:  670nMAssay Description:Inhibition of FNIP1 in human HEK293T cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50611347(CHEMBL5277462)
Affinity DataIC50:  7.60E+3nMAssay Description:Binding affinity to BRD4 bromodomain 1 in human Ramos cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataEC50:  150nMAssay Description:Activation of caspase 3/7 in human 22Rv1 cells by Caspase-Glo reagent based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50611348(CHEMBL5289751)
Affinity DataEC50:  2nMAssay Description:Activation of caspase 3/7 in human 22Rv1 cells by Caspase-Glo reagent based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  740nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
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TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50611349(CHEMBL5283149)
Affinity DataKd:  180nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBromodomain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  740nMAssay Description:Binding affinity to BRD2 BD1 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611349(CHEMBL5283149)
Affinity DataKd:  180nMAssay Description:Binding affinity to BRD2 BD1 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  66nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
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Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))TBA
LigandPNGBDBM50611349(CHEMBL5283149)
Affinity DataKd:  47nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataEC50:  90nMAssay Description:Activation of caspase 3/7 in human 22Rv1 cells by Caspase-Glo reagent based analysisMore data for this Ligand-Target Pair
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TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  115nMAssay Description:Binding affinity to BRD4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetBromodomain-containing protein 3(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  115nMAssay Description:Binding affinity to BRD3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetBromodomain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  115nMAssay Description:Binding affinity to BRD2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50512415(CHEMBL4226052)
Affinity DataKd:  28nMAssay Description:Binding affinity to BRD4 BD1 in human Burkitts lymphoma cells assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetProtein cereblon(Homo sapiens (Human))TBA
LigandPNGBDBM50512415(CHEMBL4226052)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to CRBN in human Burkitts lymphoma cells assessed as dissociation constantMore data for this Ligand-Target Pair
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