Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50018814
TargetSmoothened homolog(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50612861BDBM50612861(CHEMBL5276628)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at SMO D473H mutant (unknown origin) expressed in mouse TM3 cells coexpressing Gli-luc reporter gene assessed as inhibition of Hh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSonic hedgehog protein(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50612865BDBM50612865(CHEMBL5276737)
Affinity DataKd:  170nMAssay Description:Binding affinity to Shh (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetZinc finger protein GLI1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378034BDBM50378034(NSC-287088 | PHYSALIN B | CHEMBL504404)
Affinity DataIC50: 600nMAssay Description:Inhibition of GLI1 (unknown origin) transcriptional activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetZinc finger protein GLI1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50612863BDBM50612863(CHEMBL5281322)
Affinity DataIC50: 700nMAssay Description:Inhibition of GLI1 (unknown origin) transcriptional activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetZinc finger protein GLI1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50557557BDBM50557557(CHEMBL504910)
Affinity DataIC50: 700nMAssay Description:Inhibition of GLI1 (unknown origin) transcriptional activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetZinc finger protein GLI1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50612864BDBM50612864(CHEMBL5280113)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of GLI1 (unknown origin) transcriptional activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetZinc finger protein GLI1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50607892BDBM50607892(CHEBI:3914 | (+)-Crinamine | CHEMBL516991)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells coexpressing luciferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetZinc finger protein GLI1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50612862BDBM50612862(CHEMBL5271777)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells coexpressing luciferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetZinc finger protein GLI1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50221066BDBM50221066(9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alp...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells coexpressing luciferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed