Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50020734
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM20315(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)
Affinity DataIC50: 0.110nMAssay Description:Antagonist activity at TRPV1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at TRPV4 (unknown origin) assessed as inhibition of capsaicin induced Ca2+ influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM20532(7-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50086717(JNJ-39439335 | Mavatrep)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293T cells assessed as inhibition of capsaicin-induced TRPV1 channel activation by FLI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50633196(CHEMBL5398782)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human recombinant TPRV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50058046(propofol | CHEMBL526)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of TRPV1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50633194(CHEMBL5435976)
Affinity DataKi:  7.80nMAssay Description:Binding affinity to human TRPV1 assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM20321(JYL1421 | CHEMBL388824 | 3-[(4-tert-butylphenyl)me...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at TRPV1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50633198(CHEMBL5404899)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293T cells assessed as inhibition of capsaicin-induced TRPV1 channel activation by FLI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM236114(US9365563, Z1 | US9878991, Compound Z1)
Affinity DataIC50: 34nMAssay Description:Agonist activity at human TRPV1 overexpressed in HEK293 cells incubated for 1 hr by Fluo-4 AM dye based microscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50133817(BCTC | CHEMBL441472 | N-(4-tert-butylphenyl)-4-(3-...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM236099(US9365563, K1 | US9878991, Compound K1)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293F cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ level by FLI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM236102(US9365563, N1 | US9878991, Compound N1)
Affinity DataIC50: 39nMAssay Description:Agonist activity at human TRPV1 overexpressed in HEK293 cells incubated for 1 hr by Fluo-4 AM dye based microscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50212311(4-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...)
Affinity DataIC50: 65nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50633195(CHEMBL5430171)
Affinity DataIC50: 84nMAssay Description:Activation of human TRPV1 expressed in HEK293F cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50633193(CHEMBL367892)
Affinity DataIC50: 106nMAssay Description:Antagonist activity at TRPV1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50633197(Jts-653 | JTS653 | JTS-653)
Affinity DataIC50: 236nMAssay Description:Antagonist activity at human recombinant TPRV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM20461(Zostrix | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl...)
Affinity DataIC50: 313nMAssay Description:Activation of human TRPV1 expressed in HEK293F cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily V member 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM20461(Zostrix | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl...)
Affinity DataIC50: 420nMAssay Description:Inhibition of TRPV1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)