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Found 18 Enz. Inhib. hit(s) with all data for entry = 50017481
TargetType-1 angiotensin II receptor(RABBIT)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50042559(5-Butyl-2-(2-chloro-phenyl)-4-[2'-(1H-tetrazol-5-y...)
Affinity DataIC50:  0.350nMAssay Description:Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of recombinant wild-type BTK (unknown origin) assessed as inhibition of substrate phosphorylation using peptide substrate in presence of A...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(RABBIT)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50042580(2-Butyl-5-(2-chloro-phenyl)-3-[2'-(1H-tetrazol-5-y...)
Affinity DataIC50:  0.550nMAssay Description:Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50602174(CHEMBL5189739)
Affinity DataIC50:  1nMAssay Description:Inhibition of plasma kallikrein (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 58 ...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human DPP4 expressed in Silkworm baculovirus system preincubated for 30 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataIC50:  4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50602175(DA-8159 | UDENAFIL | Udenafil | Zydena)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataIC50:  14nMAssay Description:Inhibition of CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetAndrogen receptor(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50602177(CHEMBL5206636)
Affinity DataIC50:  26nMAssay Description:Inhibition of full length human AR stably expressed in human HEK293 cells assessed as luciferase activity incubated for 24 hrs by microplate luminome...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(RABBIT)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM82258(CAS_114798-26-4 | Losartan | NSC_3961)
Affinity DataIC50:  40nMAssay Description:Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)
Affinity DataIC50:  105nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50602176(CHEMBL5170320)
Affinity DataKd:  6.20nMAssay Description:Inhibition of human PI3K-delta by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed