Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50019189
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM549410(2-{4-[(1S)-1-[(4-chloro-1,6-dimethyl-1H-indol-2-yl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of wild type PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM549410(2-{4-[(1S)-1-[(4-chloro-1,6-dimethyl-1H-indol-2-yl...)
Affinity DataIC50: 106nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM549454(methyl 2-{4-[(1S)-1-[(4-chloro-1,6-dimethyl-1H-ind...)
Affinity DataIC50: 162nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616371(CHEMBL5415992)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616372(CHEMBL5436320)
Affinity DataKd:  2.33E+3nMAssay Description:Binding affinity to PHGDH (unknown origin) assessed as dissociation constant incubated for 60 mins by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616373(CHEMBL5418330)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616372(CHEMBL5436320)
Affinity DataKd:  2.48E+3nMAssay Description:Binding affinity to his-tagged PHGDH (127 to 722 residues) (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616375(CHEMBL5435562)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616372(CHEMBL5436320)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616372(CHEMBL5436320)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of wild type PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM549410(2-{4-[(1S)-1-[(4-chloro-1,6-dimethyl-1H-indol-2-yl...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of PHGDH D175A mutant (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616361(CHEMBL5440487)
Affinity DataIC50: 3.19E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616366(CHEMBL5418314)
Affinity DataIC50: 3.59E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616370(CHEMBL5404538)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616374(CHEMBL5394206)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616369(CHEMBL5412915)
Affinity DataIC50: 4.96E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616368(CHEMBL5401773)
Affinity DataIC50: 5.33E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50230362(CHEMBL4070806)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616365(CHEMBL5413529)
Affinity DataIC50: 6.16E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616360(CHEMBL5409883)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616376(CHEMBL5426021)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616354(CHEMBL5413530)
Affinity DataIC50: 6.81E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616364(CHEMBL5405367)
Affinity DataIC50: 7.04E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616363(CHEMBL5422286)
Affinity DataIC50: 7.49E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616362(CHEMBL5411304)
Affinity DataIC50: 7.74E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616367(CHEMBL5404397)
Affinity DataIC50: 7.89E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616356(CHEMBL5439942)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616355(CHEMBL5403306)
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616353(CHEMBL5406447)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616351(CHEMBL5424581)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616378(CHEMBL5404649)
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616352(CHEMBL5419037)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616372(CHEMBL5436320)
Affinity DataKi:  1.49E+4nMAssay Description:Competitive inhibition of PHGDH (unknown origin) assessed as inhibition constant using 3-PG as substrate preincubated for 30 mins followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616372(CHEMBL5436320)
Affinity DataKi:  1.52E+4nMAssay Description:Competitive inhibition of PHGDH (unknown origin) assessed as inhibition constant using NAD+ as substrate preincubated for 30 mins followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616359(CHEMBL5399957)
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616358(CHEMBL5427764)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616377(CHEMBL5408434)
Affinity DataIC50: 1.72E+4nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616357(CHEMBL5427304)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616350(CHEMBL5439263)
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50616372(CHEMBL5436320)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PHGDH D175A mutant (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed