Compile Data Set for Download or QSAR
Report error Found 180 Enz. Inhib. hit(s) with all data for entry = 50020135
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626607BDBM50626607(CHEMBL5430904)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of P2X7 (unknown origin) assessed as reduction in IL-1 beta releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626608BDBM50626608(CHEMBL5429737)
Affinity DataIC50: 1nMAssay Description:Inhibition of P2X7 (unknown origin) assessed as reduction in IL-1 beta releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174787BDBM174787(US9102686, 18 | US9540388, 18 | US10053462, 18)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human P2X7 receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 254234BDBM254234(US9464084, 119 | US10112937, Example 119 | US10150...)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 254234BDBM254234(US9464084, 119 | US10112937, Example 119 | US10150...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at recombinant rat P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 505120BDBM505120(US11066409, Compound I-0003)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 254203BDBM254203(US9464084, 88 | US10112937, Example 88 | US1015076...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant rat P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 254247BDBM254247(US9464084, 133 | US10112937, Example 133 | US10150...)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 254203BDBM254203(US9464084, 88 | US10112937, Example 88 | US1015076...)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626622BDBM50626622(CHEMBL5407113)
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174777BDBM174777(US9102686, 8 | US9540388, 8 | US10053462, 8)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant rat P2X7 receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174830BDBM174830(US9102686, 61 | US9540388, 61 | US10053462, 61)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human P2X7 receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 254380BDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at recombinant rat P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626621BDBM50626621(CHEMBL5440534)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 254157BDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 3.10nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 254190BDBM254190(US9464084, 75 | US10112937, Example 75 | US1015076...)
Affinity DataIC50: 3.40nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174770BDBM174770(US9102686, 1 | US9540388, 1 | US10053462, 1)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant human P2X7 receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626620BDBM50626620(CHEMBL5416813)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174787BDBM174787(US9102686, 18 | US9540388, 18 | US10053462, 18)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of recombinant rat P2X7 receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174770BDBM174770(US9102686, 1 | US9540388, 1 | US10053462, 1)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant rat P2X7 receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626623BDBM50626623(CHEMBL5399698)
Affinity DataIC50: 5.70nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 446067BDBM446067(2-chloro-6-fluoro-N-(2-{4-[(3-fluorophenyl)methoxy...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human P2X7 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 254380BDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174772BDBM174772(US9102686, 3 | US9540388, 3 | US10053462, 3)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of recombinant rat P2X7 receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 254190BDBM254190(US9464084, 75 | US10112937, Example 75 | US1015076...)
Affinity DataIC50: 9.10nMAssay Description:Antagonist activity at recombinant rat P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50414309BDBM50414309(CHEMBL551362)
Affinity DataIC50: 9.30nMAssay Description:Antagonist activity at P2X7 in human THP-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 254247BDBM254247(US9464084, 133 | US10112937, Example 133 | US10150...)
Affinity DataIC50: 9.30nMAssay Description:Antagonist activity at recombinant rat P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174772BDBM174772(US9102686, 3 | US9540388, 3 | US10053462, 3)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of recombinant human P2X7 receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174777BDBM174777(US9102686, 8 | US9540388, 8 | US10053462, 8)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of recombinant human P2X7 receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626624BDBM50626624(CHEMBL5411789)
Affinity DataIC50: 9.70nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 398085BDBM398085(US10323000, Compound 21 | (R)-4-chloro-N-((3,3-dif...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50267791BDBM50267791(AZD-9056 | AZD9056)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor in human blood assessed as ATP induced IL-1 betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626618BDBM50626618(CHEMBL5419802)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 398206BDBM398206(US10323000, Compound 143 | Preparations of 4-chlor...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626625BDBM50626625(CHEMBL5439271)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 398147BDBM398147(US10323000, Compound 83 | 4-chloro-N-((1-hydroxy-3...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174819BDBM174819(US9102686, 50 | US9540388, 50 | US10053462, 50)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human P2X7 receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 398071BDBM398071(US10323000, Compound 7 | US10676433, Compound 7)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626629BDBM50626629(CHEMBL5441025)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626626BDBM50626626(CHEMBL5397742)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626632BDBM50626632(CHEMBL5408168)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626633BDBM50626633(CHEMBL5404182)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626630BDBM50626630(CHEMBL5428254)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 505130BDBM505130(US11066409, Compound I-0111 | US11066409, Compound...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 505144BDBM505144(US11066409, Compound I-0188)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 505150BDBM505150(US11066409, Compound I-0007)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 505168BDBM505168(US11066409, Compound I-0026)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626612BDBM50626612(CHEMBL5419822)
Affinity DataIC50: 10nMAssay Description:Inhibition of human P2X7 receptor in HEK cells by fluorescence based calcium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 505240BDBM505240(US11066409, Compound I-0110 | US11066409, Compound...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 505147BDBM505147(US11066409, Compound I-0002)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
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