Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50019359
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618516(CHEMBL5427912)
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease incubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence based ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618517(CHEMBL5435801)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease incubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence based ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618522(CHEMBL5412640)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease incubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence based ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM31524(Naphthalene and Benzamide Derivative, 25 | 5-amino...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease incubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence based ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618518(CHEMBL5408904)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease incubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence based ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618521(CHEMBL5426936)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease incubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence based ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM31524(Naphthalene and Benzamide Derivative, 25 | 5-amino...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease assessed as deubiquitination activity using ubiquitinated fluorogenic as substrate incubated for 2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618523(CHEMBL5440578)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease incubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence based ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618524(CHEMBL5401448)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease incubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence based ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618525(CHEMBL5400721)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease incubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence based ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618520(CHEMBL5410072)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease incubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence based ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618519(CHEMBL5414278)
Affinity DataIC50: 7.20E+4nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease incubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence based ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618517(CHEMBL5435801)
Affinity DataIC50: 1.34E+5nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrate measured after 30 mins in presence of NADPH by UPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618516(CHEMBL5427912)
Affinity DataIC50: 3.90E+5nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease assessed as deubiquitination activity using ubiquitinated fluorogenic as substrate incubated for 2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618517(CHEMBL5435801)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human CYP2D6 measured after 40 mins in presence of NADPH by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618516(CHEMBL5427912)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human CYP2C9 measured after 30 mins in presence of NADPH by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618517(CHEMBL5435801)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human CYP2C9 measured after 30 mins in presence of NADPH by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618516(CHEMBL5427912)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrate measured after 30 mins in presence of NADPH by UPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50618516(CHEMBL5427912)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human CYP2D6 measured after 40 mins in presence of NADPH by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed