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Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50022279
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50014323(CHEMBL283196 | alpha-naphthoflavone | 2-PHENYL-4H-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650204(CHEMBL5624912)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human CYP1B1 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650204(CHEMBL5624912)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650204(CHEMBL5624912)
Affinity DataKi:  3.90nMAssay Description:Competitive inhibition of human CYP1B1 overexpressed in CHO cells assessed as protein catalyzed 7-ER O-deethylation by kinetic analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50486850(CHEMBL58557)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650195(CHEMBL5631026)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650197(CHEMBL5630901)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650202(CHEMBL5630146)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50627069(CHEMBL5414115)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650200(CHEMBL5624595)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650199(CHEMBL5631046)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650196(CHEMBL5630137)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650201(CHEMBL5630143)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650190(CHEMBL5624509)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50572884(CHEMBL571956)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50278865(WR-072952 | 3-phenyl-1-p-tolylprop-2-en-1-one | CH...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650198(CHEMBL5625150)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650203(CHEMBL5624463)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650187(CHEMBL464697)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650188(CHEMBL227561)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650189(CHEMBL5631027)
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650194(CHEMBL5630516)
Affinity DataIC50: 61nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650191(CHEMBL5624485)
Affinity DataIC50: 62nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650192(CHEMBL5631062)
Affinity DataIC50: 73nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM76552((E)-1-[4-(dimethylamino)phenyl]-3-phenyl-2-propen-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50141532(1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one (6) | ...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650193(CHEMBL5630778)
Affinity DataIC50: 197nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650185(CHEMBL286151)
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM29143(Chalcone, 13 | CHEMBL7976 | cid_637760 | Chalcone ...)
Affinity DataIC50: 305nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650204(CHEMBL5624912)
Affinity DataIC50: 550nMAssay Description:Inhibition of human CYP1B1 overexpressed in CHO cells assessed as protein catalyzed estradiol hydroxylation in living cells by measuring residual act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50650186(CHEMBL463017)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of human recombinant CYP1B1 assessed as fluorescence of resorufinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50014323(CHEMBL283196 | alpha-naphthoflavone | 2-PHENYL-4H-...)
Affinity DataIC50: 2.77E+3nMAssay Description:Inhibition of human CYP1B1 overexpressed in CHO cells assessed as protein catalyzed estradiol hydroxylation in living cells by measuring residual act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)