Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50022409
TargetGlycogen synthase kinase-3 beta(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50651877(CHEMBL5639224)
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-tagged GSK3beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM7266(cid_3820 | NSC 664704 | 9-bromopaullone | 14-bromo...)
Affinity DataIC50: 4nMAssay Description:Inhibition of GSK3beta (unknown origin) expressed in Sf9 cells incubated for 30 mins in presence of [gamma32P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50651877(CHEMBL5639224)
Affinity DataIC50: 4nMAssay Description:Inhibition of GSK3beta (unknown origin) expressed in Sf9 cells incubated for 30 mins in presence of [gamma32P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM7497(14-bromo-3,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^{...)
Affinity DataIC50: 4nMAssay Description:Inhibition of GSK3beta (unknown origin) expressed in Sf9 cells incubated for 30 mins in presence of [gamma32P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of NLRP3 in mouse BMDMsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of NLRP3 in human MDMsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM7497(14-bromo-3,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^{...)
Affinity DataIC50: 18nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50505855(CHEMBL4468698)
Affinity DataIC50: 42nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-induced mouse BMDMs assessed as decrease in IL-1beta release preincubated for 30 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM7781(4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione ...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of GSK3beta (unknown origin) using GS-1 as substrate incubated for 20 mins in presence of gamma-32P[ATP] by liquid scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50229962(N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)U...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of GSK3beta (unknown origin) expressed in 3T3 cells assessed as reduction in tau phosphorylation incubated 4 hrs by Western blotting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50019164(CHEMBL1164165)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-induced human J774.A1 cells assessed as reduction in IL-1beta release preincubated for 1 hr followed by ATP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50505851(CHEMBL4583133)
Affinity DataIC50: 8.45E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS/ATP-induced mouse J774.A1 assessed as decrease in IL-1beta release incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50505852(CHEMBL4538032)
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of recombinant human NLRP3 ATPase preincubated for 15 mins followed by ATP addition and measured after 40 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50229962(N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)U...)
Affinity DataIC50: 1.04E+5nMAssay Description:Inhibition of recombinant human GSK3beta using biotin-AAEELDSRAGS(PO3H2)PQL as substrate preincubated for 10 to 15 mins followed by gamma-32P[ATP] an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)