Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50022431
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50652199(CHEMBL5639998)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of SOS1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50652199(CHEMBL5639998)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in pERK level incubated for 24 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50601084(CHEMBL5192659 | US11702418, Example 12-10)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as inhibition constant by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50652199(CHEMBL5639998)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as inhibition constant by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50590049(CHEMBL5209105)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of SOS1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 4nMAssay Description:Inhibition of SOS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50590051(CHEMBL5184590)
Affinity DataIC50: 5nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in pERK level incubated for 24 hrs by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50590051(CHEMBL5184590)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of SOS1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human SOS1/GST-tagged KRAS G12C mutant (unknown origin) protein-protein interaction expressed in Escherichia coli BL21(DE3) measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 17nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in pERK level incubated for 24 hrs by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant SOS1/KRAS G12D mutant protein-protein interaction expressed in Escherichia coli BL21 (DE3) cells incubated for 3 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50652201(CHEMBL5647340)
Affinity DataIC50: 21nMAssay Description:Inhibition of SOS1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50459449(CHEMBL4213025)
Affinity DataKd:  44nMAssay Description:Binding affinity to GST-tagged human SOS1 (564 to 1049 residues) expressed in Escherichia coli BL21 (DE3) cells assessed dissociation constant incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50652200(CHEMBL5639304)
Affinity DataIC50: 72nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in pERK level incubated for 24 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50406166(CHEMBL5274267)
Affinity DataIC50: 95nMAssay Description:Inhibition of SOS1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM657521(US20240083857, Example 200 | US20240083857, Exampl...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant SOS1/KRAS G12D mutant protein-protein interaction expressed in Escherichia coli BL21 (DE3) cells incubated for 3 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant SOS1/KRAS G12D mutant protein-protein interaction expressed in Escherichia coli BL21 (DE3) cells incubated for 3 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of human recombinant SOS1/KRAS G12D mutant protein-protein interaction expressed in Escherichia coli BL21 (DE3) cells incubated for 3 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50652199(CHEMBL5639998)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed