Compile Data Set for Download or QSAR
Report error Found 52 Enz. Inhib. hit(s) with all data for entry = 50019592
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50:  850nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620792(CHEMBL5399551)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at human TGR5 transfected in HEK293T cells by CRE-driven luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620805(CHEMBL5431182)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620812(CHEMBL5409189)
Affinity DataEC50:  3.00E+3nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620803(CHEMBL5416586)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620811(CHEMBL5396857)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21681(23(S)-Methyl-3alpha,7alpha, 12alpha-trihydroxy-5be...)
Affinity DataEC50:  4.50E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620796(CHEMBL5438844)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620813(CHEMBL5436516)
Affinity DataEC50:  5.60E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620812(CHEMBL5409189)
Affinity DataEC50:  6.80E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620800(CHEMBL5440980)
Affinity DataEC50:  8.40E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620795(CHEMBL5425544)
Affinity DataEC50:  9.00E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620794(CHEMBL5435161)
Affinity DataEC50:  1.60E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620799(CHEMBL5412957)
Affinity DataEC50:  1.75E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620801(CHEMBL5424633)
Affinity DataEC50:  1.90E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620793(CHEMBL5430282)
Affinity DataEC50:  2.00E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620809(CHEMBL5420121)
Affinity DataEC50:  2.20E+4nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620813(CHEMBL5436516)
Affinity DataEC50:  2.35E+4nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620811(CHEMBL5396857)
Affinity DataEC50:  2.70E+4nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620808(CHEMBL5408411)
Affinity DataEC50:  3.50E+4nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21680(Cholic Acid | (R)-4-((3R,5S,7R,8R,10S,12S,13R,14S,...)
Affinity DataEC50:  4.15E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620804(CHEMBL5433595)
Affinity DataEC50:  4.40E+4nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620807(CHEMBL5426065)
Affinity DataEC50:  4.47E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620800(CHEMBL5440980)
Affinity DataEC50:  4.50E+4nMAssay Description:Activation of GST-tagged PXR (unknown origin) by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620802(CHEMBL5407394)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620810(CHEMBL5437734)
Affinity DataEC50:  5.20E+4nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620795(CHEMBL5425544)
Affinity DataEC50:  5.50E+4nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21680(Cholic Acid | (R)-4-((3R,5S,7R,8R,10S,12S,13R,14S,...)
Affinity DataEC50:  7.30E+4nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620796(CHEMBL5438844)
Affinity DataEC50:  7.65E+4nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620798(CHEMBL5424602)
Affinity DataEC50:  9.00E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620793(CHEMBL5430282)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620794(CHEMBL5435161)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620797(CHEMBL5411038)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620798(CHEMBL5424602)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21681(23(S)-Methyl-3alpha,7alpha, 12alpha-trihydroxy-5be...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21682((2R,4R)-2-methyl-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620799(CHEMBL5412957)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620800(CHEMBL5440980)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620803(CHEMBL5416586)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620801(CHEMBL5424633)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620797(CHEMBL5411038)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620802(CHEMBL5407394)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21682((2R,4R)-2-methyl-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620807(CHEMBL5426065)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620805(CHEMBL5431182)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620806(CHEMBL5422960)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of GST-tagged FXR LBD (unknown origin) using biotinylated Src-1 peptide as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620804(CHEMBL5433595)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620808(CHEMBL5408411)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50620809(CHEMBL5420121)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
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