Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50020838
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19423(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidoben...)
Affinity DataKi:  5.40nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells assessed as inhibition constant using Ac-LGK(Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells assessed as inhibition constant using Ac-LGK(Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633980(CHEMBL5393987)
Affinity DataKi:  6.20nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells assessed as inhibition constant using Ac-LGK(Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633978(CHEMBL5411914)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC1 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633979(CHEMBL5400421)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC1 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633978(CHEMBL5411914)
Affinity DataKi:  9.80nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells assessed as inhibition constant using Ac-LGK(Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633980(CHEMBL5393987)
Affinity DataIC50: 12nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC1 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataKi:  13nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells assessed as inhibition constant using Ac-LGK(Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633978(CHEMBL5411914)
Affinity DataIC50: 17nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633979(CHEMBL5400421)
Affinity DataIC50: 19nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633979(CHEMBL5400421)
Affinity DataKi:  22nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells assessed as inhibition constant using Ac-LGK(Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 38nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 55nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC1 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633980(CHEMBL5393987)
Affinity DataIC50: 68nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 101nMAssay Description:Inhibition of full-length recombinant human C-terminal His-tagged HDAC8 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 8(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633979(CHEMBL5400421)
Affinity DataIC50: 4.45E+3nMAssay Description:Inhibition of full-length recombinant human C-terminal His-tagged HDAC8 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633978(CHEMBL5411914)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full-length recombinant human C-terminal His-tagged HDAC8 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNuclear receptor corepressor 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633979(CHEMBL5400421)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human HDAC3/human GST-tagged NCOR1 (397 to 503 residues) using K(Ac)382 peptide substrate preincubated for 3 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNuclear receptor corepressor 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633980(CHEMBL5393987)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human HDAC3/human GST-tagged NCOR1 (397 to 503 residues) using K(Ac)382 peptide substrate preincubated for 3 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633980(CHEMBL5393987)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full-length recombinant human C-terminal His-tagged HDAC8 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNuclear receptor corepressor 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633978(CHEMBL5411914)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human HDAC3/human GST-tagged NCOR1 (397 to 503 residues) using K(Ac)382 peptide substrate preincubated for 3 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed