Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50020514
LigandPNGBDBM50630734(CHEMBL5411127)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633433(N-(4-(6,7-dimethoxy-4-oxo-3,4-dihydrophthalazin-1-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633470(N-(4-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phe...)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633471(N-(4-((3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50: 68nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633472(N-(4-((6,7-dimethoxy-4-oxo-3,4-dihydrophthalazin-1...)
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633473(N-(4-((6,7-dimethoxy-3-methyl-4-oxo-3,4-dihydropht...)
Affinity DataIC50: 118nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630733(CHEMBL5440717)
Affinity DataIC50: 139nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633475(N-(4-((6,7-dimethoxy-4-oxo-3,4-dihydrophthalazin-1...)
Affinity DataIC50: 166nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633478(5-((6,7-dimethoxy-3-methyl-4-oxo-3,4-dihydrophthal...)
Affinity DataIC50: 207nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633477(5-((6,7-dimethoxy-4-oxo-3,4-dihydrophthalazin-1-yl...)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633476(N-(4-((6,7-dimethoxy-3-methyl-4-oxo-3,4-dihydropht...)
Affinity DataIC50: 247nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633479(N-(3-fluoro-4-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50: 273nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633427(N-(4-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)be...)
Affinity DataIC50: 286nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633480(N-(2-fluoro-4-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50: 298nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633455(N-(4-(4-oxo-3,4-dihydrophthalazin-1-yl)-2-(trifluo...)
Affinity DataIC50: 377nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633462(N-((1-(6,7-dimethoxy-4-oxo-3,4-dihydrophthalazin-1...)
Affinity DataIC50: 395nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633461(N-((1-(4-oxo-3,4-dihydrophthalazin-1-yl)piperidin-...)
Affinity DataIC50: 441nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630736(CHEMBL5404767)
Affinity DataIC50: 454nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633435(N-(4-(6-methoxy-4-oxo-3,4-dihydrophthalazin-1-yl)b...)
Affinity DataIC50: 590nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633474(N-methyl-N-(4-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633429(N-(4-(4-oxo-3-phenyl-3,4-dihydrophthalazin-1-yl)be...)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633434(N-(4-(7-methoxy-3-methyl-4-oxo-3,4-dihydrophthalaz...)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633481(N-(3-(trifluorobenzyl methyl)-4-((4-oxo-3,4-dihydr...)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633430(N-(4-(3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)be...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633487(2-(4-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)ph...)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633482(N-(2-(trifluorobenzyl methyl)-4-((4-oxo-3,4-dihydr...)
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633458(6-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-3,4-...)
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630735(CHEMBL5429604)
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed