Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50020994
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to FKBP12 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50030448(CHEMBL269732 | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN ...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to FKBP12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50545525(CHEMBL4640049)
Affinity DataIC50: 3nMAssay Description:Inhibition of BCL6 BTB domain (5 to 129 residues) (unknown origin) expressed in Escherichia coli using 5-TAMRA-RSEIISTAPSSWVVPGP as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataKd:  12nMAssay Description:Binding affinity to FKBP12 (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM65456(pomalidomide | US9694015, 6.2 | 19171-19-8 | 4-ami...)
Affinity DataKd:  157nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as dissociation constant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataKd:  178nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as dissociation constant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMicrotubule-associated proteins 1A/1B light chain 3B(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM69688(cid_5398649 | SMR000514295 | 5,7-Dihydroxy-4-pheny...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human LC3B expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMicrotubule-associated proteins 1A/1B light chain 3B(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635847(CHEMBL5285058)
Affinity DataIC50: 200nMAssay Description:Inhibition of human LC3B expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50070114(CHEMBL468 | 2-(2,6-dioxopiperidin-3-yl)isoindoline...)
Affinity DataKd:  250nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as dissociation constant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM10890(E7070 | Sulfonamide, 7 | Compound 6 | CHEMBL77517 ...)
Affinity DataIC50: 360nMAssay Description:Inhibition of CRBN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635844(CHEMBL5560216)
Affinity DataIC50: 400nMAssay Description:Inhibition of CDK12/cyclinK (unknown origin) measured after 60 mins in presence of ATP by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRNA-binding protein 39(Homo sapiens)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635843(CHEMBL3197745)
Affinity DataIC50: 400nMAssay Description:Inhibition of RBM39 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635846(CHEMBL5568279)
Affinity DataIC50: 400nMAssay Description:Inhibition of CDK12/cyclinK (unknown origin) measured after 60 mins in presence of ATP by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635845(CHEMBL5561542)
Affinity DataIC50: 400nMAssay Description:Inhibition of CDK12/cyclinK (unknown origin) measured after 60 mins in presence of ATP by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase ZFP91(Homo sapiens)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50584761(BUFALIN | CHEBI:517248 | Bufalin)
Affinity DataKd:  462nMAssay Description:Binding affinity to ZFP91 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635842(E-7820 | E7820 | ER-68203-00)
Affinity DataKi:  2.90E+3nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as inhibition constant by TR-FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Target14-3-3 protein beta/alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635850(CHEMBL5564234)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of human full length 14-3-3beta expressed in Escherichia coli BL21 (DE3) by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCystic fibrosis transmembrane conductance regulator(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635851(CHEMBL5532317)
Affinity DataIC50: 3.61E+4nMAssay Description:Inhibition of CFTR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEstrogen receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635849(CHEMBL5280823)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of ERalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCatenin beta-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635848(CHEMBL5561355)
Affinity DataIC50: 2.06E+5nMAssay Description:Inhibition of full length GST-Tagged human beta catenin overexpressed in HEK293T cells by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed