Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50021128
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50597863(CHEMBL5188291)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of DOT1L (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50637320(CHEMBL5559161)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of PRMT5 (unknown origin) by HotSpot profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50637320(CHEMBL5559161)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PRMT4 (unknown origin) by HotSpot profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50609427(CHEMBL5289464)
Affinity DataIC50: 8.60nMAssay Description:Displacement of [3H-SAM] from full-length EZH1 (2 to 746 residues) (unknown origin) using a core histone substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50590376(CHEMBL5193486)
Affinity DataIC50: 16nMAssay Description:Displacement of [3H-SAM] from PRC2-EZH2 (unknown origin) measured after 2 hrs by SPA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50590375(CHEMBL5187396)
Affinity DataIC50: 21nMAssay Description:Displacement of [3H-SAM] from PRC2-EZH1 (unknown origin) measured after 2 hrs by SPA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50590376(CHEMBL5193486)
Affinity DataIC50: 23nMAssay Description:Displacement of [3H-SAM] from PRC2-EZH1 (unknown origin) measured after 2 hrs by SPA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50590375(CHEMBL5187396)
Affinity DataIC50: 24nMAssay Description:Displacement of [3H-SAM] from PRC2-EZH2 (unknown origin) measured after 2 hrs by SPA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50590374(CHEMBL5196503)
Affinity DataIC50: 47nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50609427(CHEMBL5289464)
Affinity DataIC50: 62nMAssay Description:Displacement of [3H-SAM] from full-length EZH2 (2 to 746 residues) (unknown origin) using a core histone substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50541920(Lirametostat | Cpi-1205)
Affinity DataIC50: 64nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells assessed as decrease in H3K9Me2 level by ICW assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50637319(CHEMBL5560847)
Affinity DataIC50: 5.73E+3nMAssay Description:Inhibition of HDAC in human K562 cells using Boc-K(Ac)-AMC as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50637319(CHEMBL5560847)
Affinity DataIC50: 7.14E+3nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells assessed as decrease in H3K9Me2 level by ICW assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50637319(CHEMBL5560847)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of HDAC in human HeLa cells using Boc-K(Ac)-AMC as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed