Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50021321
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  49nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50289535(CHEMBL4176184)
Affinity DataEC50:  81nMAssay Description:Corrector activity at wild type CFTR F508del mutant (unknown origin) expressed in BHK cells assessed as increase in chloride secretion by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50032695(CHEMBL3354673)
Affinity DataEC50:  100nMAssay Description:Potentiation of CFTR G551D mutant (unknown origin) expressed in FRT cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50185114(2-(2-chlorobenzamido)-4,5,6,7-tetrahydrobenzo[b]th...)
Affinity DataEC50:  326nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM140011(US8901310, Comparator A)
Affinity DataEC50:  400nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) in FRT cells assessed as rescue of CFTR mutant incubated for 24 hrs in presence of VX-770More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639564(CHEMBL5554989)
Affinity DataEC50:  930nMAssay Description:Activation of CFTR F508del mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639563(CHEMBL1742186)
Affinity DataEC50:  1.00E+3nMAssay Description:Activation of CFTR F508del mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639562(CHEMBL5561238)
Affinity DataEC50:  1.00E+3nMAssay Description:Potentiation of CFTR W1282X mutant (unknown origin) transfected in mouse FRT cells in presence of forskolin/VX-770More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM281054(US10022352, Compound 315)
Affinity DataEC50:  1.10E+3nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639567(CHEMBL5542877)
Affinity DataEC50:  1.90E+3nMAssay Description:Activation of CFTR F508del mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639562(CHEMBL5561238)
Affinity DataEC50:  1.90E+3nMAssay Description:Potentiation of CFTR N1303K mutant (unknown origin) transfected in mouse FRT cells in presence of forskolin/VX-770More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639566(CHEMBL5566827)
Affinity DataEC50:  2.70E+3nMAssay Description:Activation of CFTR F508del mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639565(CHEMBL5560928)
Affinity DataEC50:  3.00E+3nMAssay Description:Activation of CFTR F508del mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50289706(CHEMBL1257047)
Affinity DataEC50:  3.30E+3nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639568(CHEMBL5557028)
Affinity DataEC50:  4.20E+3nMAssay Description:Activation of CFTR F508del mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50289535(CHEMBL4176184)
Affinity DataEC50:  7.00E+3nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM7458(Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataEC50:  1.08E+4nMAssay Description:Potentiation of CFTR N1303K mutant (unknown origin) expressed in FRT cells assessed as increase in CFTR mutant activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed