Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50021261
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638865(CHEMBL5558202)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of USP7 (unknown origin) using Ub-Rh110 substrate by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50618514(CHEMBL5401467)
Affinity DataIC50: 40nMAssay Description:Inhibition of wild type UP28 (unknown origin) (1 to 651 residues) expressed in Escherichia coli BL21 (DE3) cells using Ub-AMC as substrate by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602284(CHEMBL4803149)
Affinity DataIC50: 41nMAssay Description:Inhibition of USP7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50560580(CHEMBL4759513)
Affinity DataIC50: 52nMAssay Description:Inhibition of His-tagged USP7 (unknown origin) catalytic domain (208 to 560 residues) expressed in Sf9 cells by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 76nMAssay Description:Inhibition of USP7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514122(CHEMBL4548694)
Affinity DataIC50: 90nMAssay Description:Inhibition of full length His-tagged human recombinant USP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638867(CHEMBL5558197)
Affinity DataIC50: 92nMAssay Description:Inhibition of USP7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50618513(CHEMBL5431014)
Affinity DataIC50: 100nMAssay Description:Inhibition of wild type UP28 (unknown origin) (1 to 651 residues) expressed in Escherichia coli BL21 (DE3) cells using Ub-AMC as substrate by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50618502(CHEMBL5398929)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant UP28More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50567586(CHEMBL4867215)
Affinity DataIC50: 193nMAssay Description:Inhibition of full length His-tagged human recombinant USP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50393446(CHEMBL2159505)
Affinity DataIC50: 400nMAssay Description:Inhibition of full length human USP7 (1 to 1102 residues) expressed in Escherichia coli BL21 (DE3) using Ubiquitin-AMC as substrate pre-incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50436151(CHEMBL2398212)
Affinity DataIC50: 420nMAssay Description:Inhibition of full length wild type human USP7 expressed in Sf9 cells using Bac-to-Bac Baculovirus system by using ubiquitin-7-amido-4-methylcoumarin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 19(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50069763(CHEMBL3407552)
Affinity DataIC50: 544nMAssay Description:Inhibition of C-terminal 6-His tagged USP19 (unknown origin) (1 to 1290 residues) using Ub-Rh110MP as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCaspase-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608543(CHEMBL4441423)
Affinity DataIC50: 580nMAssay Description:Inhibition of caspase-3 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638868(CHEMBL5559452)
Affinity DataIC50: 600nMAssay Description:Inhibition of N-terminal USP7 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM445080(US10669234, Example 19 | (S)-2-(4-(5-(Trifluoromet...)
Affinity DataIC50: 670nMAssay Description:Inhibition of recombinant wild type UCH-L1 (unknown origin) by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514121(CHEMBL4442615)
Affinity DataIC50: 700nMAssay Description:Inhibition of USP28 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638866(CHEMBL5558070)
Affinity DataIC50: 739nMAssay Description:Inhibition of USP7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50250963(CHEMBL4076247)
Affinity DataIC50: 750nMAssay Description:Inhibition of C-terminal His-tagged human USP7 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50326012(3-(acetoxyimino)-5-bromo-1-(3,4-dichlorobenzyl)ind...)
Affinity DataIC50: 810nMAssay Description:Inhibition of UCH-L1 (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608542(CHEMBL5276142)
Affinity DataIC50: 830nMAssay Description:Inhibition of N-terminal USP7 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 19(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50069764(CHEMBL3407501)
Affinity DataIC50: 880nMAssay Description:Inhibition of C-terminal 6-His tagged USP19 (unknown origin) (1 to 1290 residues) using Ub-Rh110MP as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50326014(3-(acetoxyimino)-1-(3,4-dichlorobenzyl)-5-iodoindo...)
Affinity DataIC50: 940nMAssay Description:Inhibition of UCH-L1 (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCaspase-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638869(CHEMBL158037)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of caspase-3 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608546(CHEMBL5273364)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of USP28 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50623410(CHEMBL5169329)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of USP28 (unknown origin) expressed in Escherichia coli by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50250947(CHEMBL4092976)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of C-terminal His-tagged human USP7 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638870(CHEMBL5555035)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of USP7 (unknown origin) expressed in Escherichia coli BL21 (DE3) using Ub-AMC as substrate at 5 uM by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608548(CHEMBL5267548)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of USP28 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50393450(CHEMBL2159500)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of full length human USP7 (1 to 1102 residues) expressed in Escherichia coli BL21 (DE3) using Ubiquitin-AMC as substrate pre-incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50393437(CHEMBL2159495)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human recombinant full length Hexhis-tagged USP7 expressed in Sf9 cells using Ub-EKL as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 4.41E+3nMAssay Description:Inhibition of wild type UP28 (unknown origin) (1 to 651 residues) expressed in Escherichia coli BL21 (DE3) cells using Ub-AMC as substrate by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638864(CHEMBL5559257)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of His-tagged UCH-L1 (unknown origin) expressed in Escherichia coli BL21 (DE3) by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638863(CHEMBL5562878)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of His-tagged UCH-L1 (unknown origin) expressed in Escherichia coli BL21 (DE3) by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50393440(CHEMBL2159498)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human recombinant full length Hexhis-tagged USP7 expressed in Sf9 cells using Ub-EKL as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM223976(LCAHA)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of human USP2A (258 to 605 residues) expressed in Escherichia coli BL21 (DE3) using Ub-AMC as substrate pre-incubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50437694(CHEMBL1410015)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of human recombinant GST-tagged USP7 expressed as Escherichia Rosetta 2 (DE3) cells incubated for 1 hr by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638862(CHEMBL5542250)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human UCH-L1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50465222(CHEMBL4284163)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of USP7 (unknown origin) using Ub-Rh110 substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50436149(CHEMBL2398214)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of full length His-tagged human wild type USP7 expressed in Sf9 cells using bac-to-bac baculovirus system by using ubiquitin-AMC as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50436150(CHEMBL2398213)
Affinity DataIC50: 2.81E+4nMAssay Description:Inhibition of full length His-tagged human wild type USP7 expressed in Sf9 cells using bac-to-bac baculovirus system by using ubiquitin-AMC as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608547(CHEMBL1625370)
Affinity DataIC50: 2.96E+4nMAssay Description:Inhibition of USP28 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed