Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50021008
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM350086(US10208027, Compound II-2 | 3-[3-[4-[dideuterio-(t...)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of ATR (unknown origin) by Morrison equation based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50585017(CERALASERTIB | Ceralasertib | Atr kinase inhibitor...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of ATR (unknown origin) by Morrison equation based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM724380(US20250066350, Example RP3500)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of ATR in gemcitabine-stimulated human LoVo cells assessed as decrease in CHK1 phosphorylation at Ser345 residueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM268079(2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyr...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of ATR in gemcitabine-stimulated human LoVo cells assessed as decrease in CHK1 phosphorylation at Ser345 residueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM730138(US12264155, Compound 24)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM724380(US20250066350, Example RP3500)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM350086(US10208027, Compound II-2 | 3-[3-[4-[dideuterio-(t...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM412060(US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ATR in gemcitabine-stimulated human LoVo cells assessed as decrease in CHK1 phosphorylation at Ser345 residueMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM730169(US12264155, Compound 56)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635967(CHEMBL5560075)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM268079(2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyr...)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM730175(US12264155, Compound 62)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM412060(US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of ATR (unknown origin) by Morrison equation based analysisMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM730170(US12264155, Compound 57)
Affinity DataIC50: 3nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635969(CHEMBL5562229)
Affinity DataIC50: 3nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635968(CHEMBL5542914)
Affinity DataIC50: 3nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM268079(2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyr...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of ATR (unknown origin) by Morrison equation based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635964(CHEMBL5560123)
Affinity DataIC50: 4nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM412060(US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...)
Affinity DataIC50: 5nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50427326(CHEMBL2325697)
Affinity DataIC50: 5nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM730157(US12264155, Compound 43)
Affinity DataIC50: 5nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM730117(US12264155, Compound 3)
Affinity DataIC50: 7nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635963(CHEMBL5555424)
Affinity DataIC50: 7nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM730118(US12264155, Compound 4)
Affinity DataIC50: 9nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM730117(US12264155, Compound 3)
Affinity DataIC50: 11nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635966(CHEMBL5560048)
Affinity DataIC50: 12nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50585017(CERALASERTIB | Ceralasertib | Atr kinase inhibitor...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635965(CHEMBL5558939)
Affinity DataIC50: 18nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM730116(US12264155, Compound 2)
Affinity DataIC50: 21nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM730149(US12264155, Compound 35)
Affinity DataIC50: 40nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50585017(CERALASERTIB | Ceralasertib | Atr kinase inhibitor...)
Affinity DataIC50: 47nMAssay Description:Inhibition of ATR in gemcitabine-stimulated human LoVo cells assessed as decrease in CHK1 phosphorylation at Ser345 residueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635955(CHEMBL5568570)
Affinity DataIC50: 50nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635962(CHEMBL5561193)
Affinity DataIC50: 60nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM730149(US12264155, Compound 35)
Affinity DataIC50: 64nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM350086(US10208027, Compound II-2 | 3-[3-[4-[dideuterio-(t...)
Affinity DataIC50: 74nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM350086(US10208027, Compound II-2 | 3-[3-[4-[dideuterio-(t...)
Affinity DataIC50: 85nMAssay Description:Inhibition of human full length recombinant ATM using GST-c-Myc-p53 as substrate measured after 30 mins in presence of Mg/ATP mix by ELISAMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635955(CHEMBL5568570)
Affinity DataIC50: 100nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50427326(CHEMBL2325697)
Affinity DataIC50: 130nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635957(CHEMBL5556905)
Affinity DataIC50: 160nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM412060(US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50585017(CERALASERTIB | Ceralasertib | Atr kinase inhibitor...)
Affinity DataIC50: 180nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM268079(2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyr...)
Affinity DataIC50: 330nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50427326(CHEMBL2325697)
Affinity DataIC50: 350nMAssay Description:Inhibition of human full length recombinant mTOR measured after 40 mins in presence of [gamma-33P]ATP by radiometric scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635959(CHEMBL5532160)
Affinity DataIC50: 700nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM350086(US10208027, Compound II-2 | 3-[3-[4-[dideuterio-(t...)
Affinity DataIC50: 750nMAssay Description:Inhibition of PI3K alpha (unknown origin) by kinase profiler analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635958(CHEMBL5557127)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635956(CHEMBL5518146)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50635960(CHEMBL5564966)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50427326(CHEMBL2325697)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human full length recombinant DNA-PK using GST-c-Myc-p53 as substrate measured after 30 mins in presence of Mg/ATP mix by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandPNGBDBM50427326(CHEMBL2325697)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PI3K alpha (unknown origin) by kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
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