Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50021690
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 81nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 126nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 226nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 226nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 234nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 279nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 344nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 358nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 358nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 365nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 379nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 456nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 497nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 721nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 918nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of PRMT1 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of PRMT4 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 6.89E+3nMAssay Description:Inhibition of PRMT1 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 8(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PRMT8 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PRMT4 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NSD3 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NSD2 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NSD2 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 8(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PRMT8 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin) using SAM and peptide substrate by HTRF assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin) using SAM and peptide substrate by HTRF assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Chinese Academy of Sciences
Curated by ChEMBL
University of Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NSD3 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair


3D Structure (crystal)
































