Compile Data Set for Download or QSAR
Report error Found 154 Enz. Inhib. hit(s) with all data for entry = 50021148
TargetMonocarboxylate transporter 4(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 356790BDBM356790(US10214492, Example 155 | US11292767, Example 155)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of MCT4 in human MDA-MB-231 cells by BCECF-AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21986BDBM21986(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity to human MCT1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637416BDBM50637416(CHEMBL5559179)
Affinity DataKi:  0.330nMAssay Description:Binding affinity to human MCT1 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22001BDBM22001(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity to human MCT1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 356906BDBM356906(US10214492, Example 257 | US11292767, Example 257)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of MCT4 in human MDA-MB-231 cells by BCECF-AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637417BDBM50637417(CHEMBL5562438)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of MCT4 in human MDA-MB-231 cells by BCECF-AM dye based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 356805BDBM356805(US10214492, Example 167 | US11292767, Example 167)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of MCT4 in human MDA-MB-231 cells by BCECF-AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50130745BDBM50130745(CHEMBL3633555)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human CA IX preincubated for 15 mins by stopped-flow instrument based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21998BDBM21998(6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-{[(4S)-...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human MCT1 assessed as inhibition constant preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637429BDBM50637429(CHEMBL5561246)
Affinity DataKi:  1.30nMAssay Description:Competitive inhibition of human CA IX using 4-nitrophenyl acetate as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50471224BDBM50471224(CHEMBL64889)
Affinity DataIC50: 2nMAssay Description:Inhibition of NHE1 in human Platelet assessed as reduction in 22Na+ uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637427BDBM50637427(CHEMBL5542693)
Affinity DataKi:  2.60nMAssay Description:Competitive inhibition of human CA IX using 4-nitrophenyl acetate as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334361BDBM50334361(4-(3-(2-isopropylphenyl)ureido)benzenesulfonamide ...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human CA IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637430BDBM50637430(CHEMBL5517832)
Affinity DataKi:  4.5nMAssay Description:Competitive inhibition of human CA IX using 4-nitrophenyl acetate as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637460BDBM50637460(CHEMBL5532364)
Affinity DataIC50: 6nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50158510BDBM50158510(CHEMBL1369708)
Affinity DataKi:  6.5nMAssay Description:Inhibition of human CA IX preincubated for 15 mins by stopped-flow instrument based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50137552BDBM50137552(5-[(1R,3S)-3-(3,5-Dichloro-phenyl)-2,2-dimethyl-cy...)
Affinity DataIC50: 8nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Rat)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092069BDBM50092069(CHEMBL3582422 | US9296728, 20)
Affinity DataIC50: 8nMAssay Description:Inhibition of MCT1 in rat RBE4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637422BDBM50637422(CHEMBL5565590)
Affinity DataKi:  8.90nMAssay Description:Inhibition of human CA IXMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104844BDBM50104844(N-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dim...)
Affinity DataIC50: 9nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Rat)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092072BDBM50092072(CHEMBL3582419 | US9296728, 14)
Affinity DataIC50: 9nMAssay Description:Inhibition of MCT1 in rat RBE4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637452BDBM50637452(CHEMBL5562362)
Affinity DataIC50: 10nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Rat)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50608638BDBM50608638(CHEMBL4303684 | US20240091210, Compound UK5099)
Affinity DataIC50: 13nMAssay Description:Inhibition of MCT1 in rat RBE4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092072BDBM50092072(CHEMBL3582419 | US9296728, 14)
Affinity DataIC50: 14nMAssay Description:Inhibition of MCT4 in human MDA-MB-231 cells by lactate transport assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334349BDBM50334349(4-(3-(3-nitrophenyl)ureido)benzenesulfonamide | 4-...)
Affinity DataKi:  15nMAssay Description:Inhibition of human CA IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50588869BDBM50588869(CHEMBL5185944)
Affinity DataKi:  16nMAssay Description:Inhibition of human CA IX preincubated with compound for 15 mins by phenol red dye based stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637457BDBM50637457(CHEMBL5550005)
Affinity DataIC50: 17nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637437BDBM50637437(CHEMBL5556414)
Affinity DataKi:  22nMAssay Description:Inhibition of human CA IX by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092069BDBM50092069(CHEMBL3582422 | US9296728, 20)
Affinity DataIC50: 23nMAssay Description:Inhibition of MCT4 in human MDA-MB-231 cells by lactate transport assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230196BDBM50230196(CHEMBL4096350)
Affinity DataKi:  24nMAssay Description:Inhibition of human CA IXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50471171BDBM50471171(CHEMBL62025)
Affinity DataIC50: 25nMAssay Description:Inhibition of NHE1 in human Platelet assessed as reduction in 22Na+ uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50589103BDBM50589103(CHEMBL5177984)
Affinity DataKi:  27nMAssay Description:Inhibition of human CA IX by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637421BDBM50637421(CHEMBL5564961)
Affinity DataKi:  27nMAssay Description:Inhibition of human CA IXMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637433BDBM50637433(CHEMBL5555730)
Affinity DataKi:  28nMAssay Description:Inhibition of human CA IX incubated for 15 mins by stopped-flow instrument based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637433BDBM50637433(CHEMBL5555730)
Affinity DataKi:  28nMAssay Description:Inhibition of human CA IX by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637427BDBM50637427(CHEMBL5542693)
Affinity DataKi:  28nMAssay Description:Inhibition of human CA IXMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637441BDBM50637441(CHEMBL5559986)
Affinity DataKi:  32nMAssay Description:Inhibition of human CA IX by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50158510BDBM50158510(CHEMBL1369708)
Affinity DataKi:  33nMAssay Description:Inhibition of human CA II preincubated for 15 mins by stopped-flow instrument based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637439BDBM50637439(CHEMBL5561109)
Affinity DataKi:  36nMAssay Description:Inhibition of human CA IX by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606665BDBM50606665(SYROSINGOPINE | Syrosingopine | Isotense | Londomi...)
Affinity DataIC50: 40nMAssay Description:Inhibition of MCT4 in human HAP1 cells by lactate transport assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637422BDBM50637422(CHEMBL5565590)
Affinity DataKi:  44nMAssay Description:Inhibition of human CA IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146756BDBM50146756(4-(3-Pentafluorophenyl-ureido)-benzenesulfonamide ...)
Affinity DataKi:  50nMAssay Description:Inhibition of human CA IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50442711BDBM50442711(CHEMBL2442509)
Affinity DataIC50: 59nMAssay Description:Inhibition of MCT1 in human SiHa cells by lactate reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSodium/hydrogen exchanger 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50097898BDBM50097898(N-(5-Cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-car...)
Affinity DataIC50: 59nMAssay Description:Inhibition of NHE1 in human Platelet assessed as change in intracellular pH by pH-sensitive BCECF-AM fluorescence probe methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637423BDBM50637423(CHEMBL5532036)
Affinity DataKi:  62nMAssay Description:Inhibition of human CA IXMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50158510BDBM50158510(CHEMBL1369708)
Affinity DataIC50: 65nMAssay Description:Inhibition of human CA I preincubated for 15 mins by stopped-flow instrument based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Rat)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50608639BDBM50608639(CHEMBL4793546)
Affinity DataIC50: 66nMAssay Description:Inhibition of MCT1 in rat RBE4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Rat)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092059BDBM50092059(CHEMBL3582407)
Affinity DataIC50: 66nMAssay Description:Inhibition of MCT1 in rat RBE4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353115BDBM50353115(CHEMBL1829127)
Affinity DataIC50: 68nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium/hydrogen exchanger 1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104860BDBM50104860(N-(2,2-Dimethyl-3-phenyl-cyclopropanecarbonyl)-gua...)
Affinity DataIC50: 69nMAssay Description:Inhibition of NHE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
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