Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50021268
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human PARP1 incubated for 90 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM715312(US20250026748, Compound 476)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human DNA polymerase theta (67 to 970 residues) ATPase activity expressed in Sf9 insect cells incubated for 40 mins by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM715312(US20250026748, Compound 476)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50638920(CHEMBL5556723)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human PARP1 incubated for 90 mins by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human PARP1 incubated for 90 mins by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of PARP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 46nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 51nMAssay Description:Inhibition of PARP3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638921(CHEMBL5555891)
Affinity DataIC50: 60nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638920(CHEMBL5556723)
Affinity DataIC50: 72nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638919(CHEMBL5564238)
Affinity DataIC50: 79nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 88nMAssay Description:Inhibition of DNA polymerase theta mediated TMEJ repair activity in HEK293 cells incubated for 24 hrs by Nano-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638914(CHEMBL5558738)
Affinity DataIC50: 117nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 156nMAssay Description:Inhibition of PARP5b (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638912(CHEMBL5556040)
Affinity DataIC50: 166nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 194nMAssay Description:Inhibition of PARP7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM715312(US20250026748, Compound 476)
Affinity DataIC50: 200nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) (1 to 899 residues) ATPase activity by NADH oxidation-coupled enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM714977(US20250026748, Compound 141)
Affinity DataIC50: 200nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) (1 to 899 residues) ATPase activity by NADH oxidation-coupled enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 206nMAssay Description:Inhibition of PARP5a (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638910(CHEMBL5555002)
Affinity DataIC50: 268nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 292nMAssay Description:Inhibition of PARP5b (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 382nMAssay Description:Inhibition of PARP10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 631nMAssay Description:Inhibition of PARP7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 660nMAssay Description:Inhibition of PARP5a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638911(CHEMBL5558560)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638916(CHEMBL5556293)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638915(CHEMBL5559805)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638913(CHEMBL5567364)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638918(CHEMBL5558038)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50638917(CHEMBL5564092)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PARP10 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of PARP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibition of PARP8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human DNA polymerase theta (67 to 970 residues) ATPase activity expressed in Sf9 insect cells incubated for 40 mins by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 2.44E+4nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 9.23E+4nMAssay Description:Inhibition of DNA polymerase theta mediated TMEJ repair activity in HEK293 cells incubated for 24 hrs by Nano-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed