Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50020901
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataKi: <0.0500nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of HPK1 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 0.360nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 0.430nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 0.490nMAssay Description:Inhibition of GLK (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 4.10nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 7.5nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 9.80nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP76 phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal nanoluc-fused HPK1 (unknown origin) expressed in HEK293T cells preincubated for 2 hrs in presence of cell permeable fluoresc...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of N-terminal nanoluc-fused HPK1 (unknown origin) expressed in HEK293T cells preincubated for 2 hrs in presence of cell permeable fluoresc...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 132nMAssay Description:Inhibition of HPK1 in human PBMC cells assessed as inhibition of SLP76 phosphorylation pretreated for 1 hr followed by anti-CD3/CD28 addition and mea...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 148nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of SLP76 phosphorylation pretreated for 1 hr followed by anti-CD3/CD28 addition and m...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 154nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP76 phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP76 phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP76 phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of N-terminal nanoluc-fused HPK1 (unknown origin) expressed in HEK293T cells preincubated for 2 hrs in presence of cell permeable fluoresc...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP76 phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP76 phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of N-terminal nanoluc-fused HPK1 (unknown origin) expressed in HEK293T cells preincubated for 2 hrs in presence of cell permeable fluoresc...More data for this Ligand-Target Pair
