Compile Data Set for Download or QSAR
Report error Found 52 Enz. Inhib. hit(s) with all data for entry = 50021490
TargetALK tyrosine kinase receptor(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641290(CHEMBL5593687)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of wild type ALK (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of His-tagged human recombinant wild type RET M918T mutant expressed in Sf9 cells using poly(Glu, Tyr) peptide as substrate in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM296432(US10112942, Example 166 | 6-(2-hydroxy-2- methylpr...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641289(CHEMBL5572034)
Affinity DataIC50: 0.950nMAssay Description:Binding affinity to human recombinant RET V804M mutant assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641293(CHEMBL5563972)
Affinity DataIC50: 1nMAssay Description:Inhibition of RET V804M mutant (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641293(CHEMBL5563972)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type VEGFR2 (unknown origin) expressed in baculovirus infected insect cells using biotinylated-GGGGQDGKDYIVLPI peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641293(CHEMBL5563972)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type human RET by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641289(CHEMBL5572034)
Affinity DataIC50: 1nMAssay Description:Binding affinity to human recombinant RET V804L mutant assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of RET G810D mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to full length human recombinant RET assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50187716(CHEMBL3735648)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of wild type His-tagged human RET by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641292(CHEMBL5572592)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of GST-tagged wild type RET (unknown origin) expressed in Sf9 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641292(CHEMBL5572592)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of RET G810A mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641289(CHEMBL5572034)
Affinity DataIC50: 1.90nMAssay Description:Binding affinity to wild type RET (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type ALK (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641290(CHEMBL5593687)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type His-tagged human RET by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type His-tagged human RET by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641289(CHEMBL5572034)
Affinity DataIC50: 3nMAssay Description:Inhibition of CCDC6-RET (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641289(CHEMBL5572034)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of full length His-tagged human recombinant RET expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50187716(CHEMBL3735648)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of wild type ALK (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of GST-tagged wild type RET (unknown origin) expressed in Sf9 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641292(CHEMBL5572592)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of RET G810V mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of RET G810A mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant RET S891A mutant using Biotin-EGPWLEEEEEAYGWMDF peptide as substrate by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant RET V804M mutant using Biotin-EGPWLEEEEEAYGWMDF peptide as substrate by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant RET V804L mutant using Biotin-EGPWLEEEEEAYGWMDF peptide as substrate by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant RET Y791F mutant using Biotin-EGPWLEEEEEAYGWMDF peptide as substrate by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant RET M918T mutant using Biotin-EGPWLEEEEEAYGWMDF peptide as substrate by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant RET G691S mutant using Biotin-EGPWLEEEEEAYGWMDF peptide as substrate by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of RET (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of wild type human recombinant RET expressed in baculovirus by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50565637(CHEMBL4791960)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of wildtype RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 8nMAssay Description:Inhibition of RET G810S mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641292(CHEMBL5572592)
Affinity DataIC50: 8nMAssay Description:Inhibition of RET G810D mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of RET G810V mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641290(CHEMBL5593687)
Affinity DataIC50: 9nMAssay Description:Inhibition of RET V804L mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641292(CHEMBL5572592)
Affinity DataIC50: 10nMAssay Description:Inhibition of RET G810S mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50187716(CHEMBL3735648)
Affinity DataIC50: 10nMAssay Description:Inhibition of RET V804M mutant (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641292(CHEMBL5572592)
Affinity DataIC50: 12nMAssay Description:Inhibition of RET G810C mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 12nMAssay Description:Inhibition of RET G810C mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 12nMAssay Description:Inhibition of RET V804M mutant (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 13nMAssay Description:Inhibition of RET V804L mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50565637(CHEMBL4791960)
Affinity DataIC50: 14nMAssay Description:Inhibition of RET V804M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641292(CHEMBL5572592)
Affinity DataIC50: 15nMAssay Description:Inhibition of RET V804M mutant (unknown origin) expressed in Sf9 cells by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641292(CHEMBL5572592)
Affinity DataIC50: 18nMAssay Description:Inhibition of RET G810R mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 20nMAssay Description:Inhibition of RET V804M mutant (unknown origin) expressed in Sf9 cells by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641290(CHEMBL5593687)
Affinity DataIC50: 23nMAssay Description:Inhibition of RET V804M mutant (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50187716(CHEMBL3735648)
Affinity DataIC50: 44nMAssay Description:Inhibition of CCDC6-RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 47nMAssay Description:Inhibition of RET G810R mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 100nMAssay Description:Inhibition of RET (unknown origin) by kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
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