Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50021710
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658049(US20240083897, Compound 2 | 5-chloro-N-[2,4-difluo...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM50643874(CHEMBL5574976)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 12nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658049(US20240083897, Compound 2 | 5-chloro-N-[2,4-difluo...)
Affinity DataEC50:  13nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658048(US20240083897, Compound 1 | 6-[3-(5-chloro-2-metho...)
Affinity DataIC50: 13nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658051(US20240083897, Compound 4 | 2-[3-(5-Chloro-2-metho...)
Affinity DataIC50: 14nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658061(US20240083897, Compound 14 | 6-[3-(5-chloro-2-meth...)
Affinity DataIC50: 15nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM50643875(CHEMBL5579682)
Affinity DataIC50: 15nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658053(US20240083897, Compound 6 | 6-[2,6-difluoro-3-(5-f...)
Affinity DataIC50: 39nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658118(US20240083897, Compound 67-1)
Affinity DataIC50: 39nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658054(US20240083897, Compound 7 | 6-[2,6-difluoro-3-(5-f...)
Affinity DataIC50: 43nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM50643874(CHEMBL5574976)
Affinity DataEC50:  46nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 20(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 47nMAssay Description:Inhibition of ZAK in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658055(US20240083897, Compound 8 | 6-[3-(5-cyano-2-methox...)
Affinity DataIC50: 63nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658074(US20240083897, Compound 27-1)
Affinity DataIC50: 69nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataEC50:  72nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 77nMAssay Description:Inhibition of GCN2 in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658051(US20240083897, Compound 4 | 2-[3-(5-Chloro-2-metho...)
Affinity DataEC50:  110nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658118(US20240083897, Compound 67-1)
Affinity DataEC50:  120nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658061(US20240083897, Compound 14 | 6-[3-(5-chloro-2-meth...)
Affinity DataEC50:  140nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658048(US20240083897, Compound 1 | 6-[3-(5-chloro-2-metho...)
Affinity DataEC50:  160nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM50643875(CHEMBL5579682)
Affinity DataEC50:  160nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658074(US20240083897, Compound 27-1)
Affinity DataEC50:  240nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM50643876(CHEMBL5590134)
Affinity DataIC50: 250nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658063(US20240083897, Compound 16 | 3-[3-(5-Chloro-2-meth...)
Affinity DataIC50: 400nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658054(US20240083897, Compound 7 | 6-[2,6-difluoro-3-(5-f...)
Affinity DataEC50:  440nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658074(US20240083897, Compound 27-1)
Affinity DataEC50:  460nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658053(US20240083897, Compound 6 | 6-[2,6-difluoro-3-(5-f...)
Affinity DataEC50:  460nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658055(US20240083897, Compound 8 | 6-[3-(5-cyano-2-methox...)
Affinity DataEC50:  750nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658051(US20240083897, Compound 4 | 2-[3-(5-Chloro-2-metho...)
Affinity DataEC50:  870nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50643874(CHEMBL5574976)
Affinity DataEC50:  1.40E+3nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658118(US20240083897, Compound 67-1)
Affinity DataEC50:  1.50E+3nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658061(US20240083897, Compound 14 | 6-[3-(5-chloro-2-meth...)
Affinity DataEC50:  1.50E+3nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658049(US20240083897, Compound 2 | 5-chloro-N-[2,4-difluo...)
Affinity DataEC50:  1.70E+3nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM50643877(CHEMBL5590151)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of RIPK2 in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of MAP2K5 in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of PIK3C2B in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM50643878(CHEMBL5570666)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658048(US20240083897, Compound 1 | 6-[3-(5-chloro-2-metho...)
Affinity DataEC50:  4.90E+3nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of PEK in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658053(US20240083897, Compound 6 | 6-[2,6-difluoro-3-(5-f...)
Affinity DataEC50:  5.80E+3nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50643875(CHEMBL5579682)
Affinity DataEC50:  6.10E+3nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataEC50:  6.90E+3nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of RIPK3 in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Nek1(Human)
Pharmaron UK Ltd.

Curated by ChEMBL
LigandPNGBDBM658050(US20240083897, Compound 3)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of NEK1 in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658054(US20240083897, Compound 7 | 6-[2,6-difluoro-3-(5-f...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658055(US20240083897, Compound 8 | 6-[3-(5-cyano-2-methox...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed